ArticleFrontiers in cellular neuroscience2014
NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- An essential role for the RNA helicase DDX6 in NMDA receptor-dependent gene silencing and dendritic spine shrinkage.Scientific reports · 2024Article
- Shenzhi Jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis.Chinese medicine · 2021Article
- Intracranial Self-Stimulation Modulates Levels of SIRT1 Protein and Neural Plasticity-Related microRNAs.Molecular neurobiology · 2020Article
- MicroRNA-34a Acutely Regulates Synaptic Efficacy in the Adult Dentate Gyrus In Vivo.Molecular neurobiology · 2020Article
- NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation.The Journal of biological chemistry · 2018Article
- MicroRNAs, miR-23a-3p and miR-151-3p, Are Regulated in Dentate Gyrus Neuropil following Induction of Long-Term Potentiation In Vivo.PloS one · 2017Article
- Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity.Neurobiology of learning and memory · 2016Review
- Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons.Scientific reports · 2016Article
- Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity.Frontiers in neuroscience · 2015Article
- Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation.Frontiers in molecular neuroscience · 2015Review
- Editorial for "Regulatory RNAs in the nervous system".Frontiers in cellular neuroscience · 2015Article
- The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Neuronal activity-dependent regulation of MicroRNAs.Molecules and cells · 2014Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
microRNAs (miRNAs) are major regulators of protein synthesis in the brain. A major goal is to identify changes in miRNA expression underlying protein synthesis-dependent forms of synaptic plasticity such as long-term potentiation (LTP). Previous analyses focused on changes in miRNA levels in total lysate samples. Here, we asked whether changes in total miRNA accurately reflect changes in the amount of miRNA bound to Argonaute protein within the miRNA-induced silencing complex (miRISC). Ago2 immunoprecipitation was used to isolate RISC-associated miRNAs following high-frequency stimulation (HFS)-induced LTP in the dentate gyrus of anesthetized rats. Using locked-nucleic acid-based PCR cards for high-throughput screening and independent validation by quantitative TaqMan RT-PCR, we identified differential regulation of Ago2-associated and total miRNA expression. The ratio of Ago2/total miRNA expression was regulated bidirectionally in a miRNA-specific manner and was largely dependent on N-methyl-D-aspartate receptor (NMDA) activation during LTP induction. The present results identify miRNA association with Ago2 as a potential control point in activity-dependent synaptic plasticity in the adult brain. Finally, novel computational analysis for targets of the Ago2-associated miRNAs identifies 21 pathways that are enriched and differentially targeted by the miRNAs including axon guidance, mTOR, MAPK, Ras, and LTP.
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