ArticlePLoS computational biology2014
Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Mutation divergence over space in tumour expansion.Journal of the Royal Society, Interface · 2023Article
- Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal "unity of ecology and evolution" pathological ecosystem.Theranostics · 2023Review
- Measuring competitive exclusion in non-small cell lung cancer.Science advances · 2022Article
- Evidence for hypoxia increasing the tempo of evolution in glioblastoma.British journal of cancer · 2020Article
- Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.Nature communications · 2019Article
- Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis.Journal of mathematical biology · 2018Article
- Stability of Control Networks in Autonomous Homeostatic Regulation of Stem Cell Lineages.Bulletin of mathematical biology · 2018Article
- A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment.PLoS computational biology · 2018Article
- Determining the control networks regulating stem cell lineages in colonic crypts.Journal of theoretical biology · 2017Article
- Stem Cell Plasticity and Niche Dynamics in Cancer Progression.IEEE transactions on bio-medical engineering · 2017Article
- Mathematical and Computational Modeling in Complex Biological Systems.BioMed research international · 2017Review
- Impact of Metabolism on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment.Frontiers in immunology · 2017Review
- Modeling head and neck cancer stem cell-mediated tumorigenesis.Cellular and molecular life sciences : CMLS · 2016Review
- Feedback Regulation in a Cancer Stem Cell Model can Cause an Allee Effect.Bulletin of mathematical biology · 2016Article
- Agent-Based Modeling of Cancer Stem Cell Driven Solid Tumor Growth.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model.PLoS computational biology · 2016Article
- Spatial and functional heterogeneities shape collective behavior of tumor-immune networks.PLoS computational biology · 2015Article
- Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance.Cancer research · 2015Review
- Evolution and phenotypic selection of cancer stem cells.PLoS computational biology · 2015Article
- Normal vs. Malignant hematopoiesis: the complexity of acute leukemia through systems biology.Frontiers in genetics · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Since the discovery of tumour initiating cells (TICs) in solid tumours, studies focussing on their role in cancer initiation and progression have abounded. The biological interrogation of these cells continues to yield volumes of information on their pro-tumourigenic behaviour, but actionable generalised conclusions have been scarce. Further, new information suggesting a dependence of tumour composition and growth on the microenvironment has yet to be studied theoretically. To address this point, we created a hybrid, discrete/continuous computational cellular automaton model of a generalised stem-cell driven tissue with a simple microenvironment. Using the model we explored the phenotypic traits inherent to the tumour initiating cells and the effect of the microenvironment on tissue growth. We identify the regions in phenotype parameter space where TICs are able to cause a disruption in homeostasis, leading to tissue overgrowth and tumour maintenance. As our parameters and model are non-specific, they could apply to any tissue TIC and do not assume specific genetic mutations. Targeting these phenotypic traits could represent a generalizable therapeutic strategy across cancer types. Further, we find that the microenvironmental variable does not strongly affect the outcomes, suggesting a need for direct feedback from the microenvironment onto stem-cell behaviour in future modelling endeavours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.