ArticlePLoS computational biology2014
Integrated text mining and chemoinformatics analysis associates diet to health benefit at molecular level.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Extraction of knowledge graph of Covid-19 through mining of unstructured biomedical corpora.Computational biology and chemistry · 2023Article
- Review
- Drug-food Interactions in the Era of Molecular Big Data, Machine Intelligence, and Personalized Health.Recent advances in food, nutrition & agriculture · 2022Review
- Network-medicine framework for studying disease trajectories in U.S. veterans.Scientific reports · 2022Article
- A Deep Learning-Based Approach for Identifying the Medicinal Uses of Plant-Derived Natural Compounds.Frontiers in pharmacology · 2020Article
- Named Entity Recognition and Relation Detection for Biomedical Information Extraction.Frontiers in cell and developmental biology · 2020Review
- Free Accessible Databases as a Source of Information about Food Components and Other Compounds with Anticancer Activity⁻Brief Review.Molecules (Basel, Switzerland) · 2019Review
- IMPPAT: A curated database of Indian Medicinal Plants, Phytochemistry And Therapeutics.Scientific reports · 2018Article
- Analysis of a large food chemical database: chemical space, diversity, and complexity.F1000Research · 2018Article
- Data-driven analysis of biomedical literature suggests broad-spectrum benefits of culinary herbs and spices.PloS one · 2018Article
- Analysis of free text in electronic health records for identification of cancer patient trajectories.Scientific reports · 2017Article
- NutriChem 2.0: exploring the effect of plant-based foods on human health and drug efficacy.Database : the journal of biological databases and curation · 2017Article
- Designing Dietary Recommendations Using System Level Interactomics Analysis and Network-Based Inference.Frontiers in physiology · 2017Article
- Propelling the paradigm shift from reductionism to systems nutrition.Genes & nutrition · 2017Article
- A corpus for plant-chemical relationships in the biomedical domain.BMC bioinformatics · 2016Article
- Article
- Developing a molecular roadmap of drug-food interactions.PLoS computational biology · 2015Article
- NutriChem: a systems chemical biology resource to explore the medicinal value of plant-based foods.Nucleic acids research · 2015Article
- Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction networks.BMC genomics · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Awareness that disease susceptibility is not only dependent on genetic make up, but can be affected by lifestyle decisions, has brought more attention to the role of diet. However, food is often treated as a black box, or the focus is limited to few, well-studied compounds, such as polyphenols, lipids and nutrients. In this work, we applied text mining and Naïve Bayes classification to assemble the knowledge space of food-phytochemical and food-disease associations, where we distinguish between disease prevention/amelioration and disease progression. We subsequently searched for frequently occurring phytochemical-disease pairs and we identified 20,654 phytochemicals from 16,102 plants associated to 1,592 human disease phenotypes. We selected colon cancer as a case study and analyzed our results in three directions; i) one stop legacy knowledge-shop for the effect of food on disease, ii) discovery of novel bioactive compounds with drug-like properties, and iii) discovery of novel health benefits from foods. This works represents a systematized approach to the association of food with health effect, and provides the phytochemical layer of information for nutritional systems biology research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.