Evidence map›Paper›PMID 24453941›Full record

ArticlePLoS biology2014

The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity.

Anissa Kempf, Bjoern Tews, Michael E Arzt, Oliver Weinmann, Franz J Obermair, Vincent Pernet, Marta Zagrebelsky, Andrea Delekate, Cristina Iobbi, Ajmal Zemmar and 7 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 94 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.

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  14. Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Anissa KempfBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Bjoern TewsBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Michael E ArztBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Oliver WeinmannBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Franz J ObermairBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Vincent PernetBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Marta ZagrebelskyZoological Institute, Division of Cellular Neurobiology, TU Braunschweig, Braunschweig, Germany.
Andrea DelekateZoological Institute, Division of Cellular Neurobiology, TU Braunschweig, Braunschweig, Germany.
Cristina IobbiZoological Institute, Division of Cellular Neurobiology, TU Braunschweig, Braunschweig, Germany.
Ajmal ZemmarBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Zorica RisticBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Miriam GulloBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Peter SpiesSchool of Life Sciences, University of Applied Life Sciences Northwestern Switzerland, Muttenz, Switzerland.
Dana DoddBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
Daniel GygaxSchool of Life Sciences, University of Applied Life Sciences Northwestern Switzerland, Muttenz, Switzerland.
Martin KorteZoological Institute, Division of Cellular Neurobiology, TU Braunschweig, Braunschweig, Germany.
Martin E SchwabBrain Research Institute, University of Zurich, and Dept. of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland.
University of Zurich · CHTechnische Universität Braunschweig · DEFHNW University of Applied Sciences and Arts · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nogo-A is a membrane protein of the central nervous system (CNS) restricting neurite growth and synaptic plasticity via two extracellular domains: Nogo-66 and Nogo-A-Δ20. Receptors transducing Nogo-A-Δ20 signaling remained elusive so far. Here we identify the G protein-coupled receptor (GPCR) sphingosine 1-phosphate receptor 2 (S1PR2) as a Nogo-A-Δ20-specific receptor. Nogo-A-Δ20 binds S1PR2 on sites distinct from the pocket of the sphingolipid sphingosine 1-phosphate (S1P) and signals via the G protein G13, the Rho GEF LARG, and RhoA. Deleting or blocking S1PR2 counteracts Nogo-A-Δ20- and myelin-mediated inhibition of neurite outgrowth and cell spreading. Blockade of S1PR2 strongly enhances long-term potentiation (LTP) in the hippocampus of wild-type but not Nogo-A(-/-) mice, indicating a repressor function of the Nogo-A/S1PR2 axis in synaptic plasticity. A similar increase in LTP was also observed in the motor cortex after S1PR2 blockade. We propose a novel signaling model in which a GPCR functions as a receptor for two structurally unrelated ligands, a membrane protein and a sphingolipid. Elucidating Nogo-A/S1PR2 signaling platforms will provide new insights into regulation of synaptic plasticity.

Indexed as

AnimalsCell ProliferationGene Expression RegulationGTP-Binding Protein alpha Subunits, G12-G13HippocampusLong-Term PotentiationLysophospholipidsMiceMice, KnockoutMotor CortexMyelin ProteinsMyelin SheathNeuritesNeuronal PlasticityNogo ProteinsProprotein ConvertasesGTP-Binding Protein alpha Subunits, G12-G13Lysophospholipidsmembrane-bound transcription factor peptidase, site 1Myelin ProteinsNogo ProteinsProprotein ConvertasesReceptors, LysosphingolipidrhoA GTP-Binding ProteinRhoA protein, mouserho GTP-Binding ProteinsRtn4 protein, mouseSerine EndopeptidasesSphingosinesphingosine 1-phosphatesphingosine-1-phosphate receptor-2, mouseSphingosine-1-Phosphate Receptors

Identifiers

PMID24453941
PMCPMC3891622
OpenAlexW1993910212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.