Evidence map›Paper›PMID 24453913›Full record

ArticleTheScientificWorldJournal2013

Investigation of chemokine receptor CCR2V64Il gene polymorphism and migraine without aura in the Iranian population.

Alireza Zandifar, Maryam Taheriun, Samira Soleimani, Faraidoon Haghdoost, Mohamadhasan Tajaddini, Shaghayegh Haghjooy Javanmard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alireza ZandifarMedical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran ; Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
Maryam TaheriunMedical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran ; Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
Samira SoleimaniMedical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran ; Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
Faraidoon HaghdoostMedical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran ; Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
Mohamadhasan TajaddiniPhysiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran ; School of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
Shaghayegh Haghjooy JavanmardPhysiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMigraine is a multifactorial common neurovascular disease with a polygenic inheritance. Inflammation plays an important part in migraine pathophysiology. C-C chemokine receptor 2 (CCR2) is an important chemokine for monocyte aggregation and transendothelial monocyte migration. The aim of our study was to investigate the association of migraine with CCR2V64Il polymorphism in the Iranian population.

methodsWe assessed 103 patients with newly diagnosed migraine and 100 healthy subjects. Genomic DNA samples were extracted from peripheral blood and genotypes of CCR2V64Il gene polymorphism were determined. For measuring the severity of headache, every patient filled out the MIGSEV questionnaire.

resultsThere were no significant differences in the distribution of both 64Il allele and heterozygote (GA) genotype of CCR2 gene polymorphism (P = 0.396; OR = 0.92, 95% CI = 0.50-1.67 and P = 0.388; OR = 0.91, 95% CI = 0.47-1.73, resp.) between case and control groups. There was no significant difference of alleles frequency between three grades of MIGSEV (P = 0.922).

conclusionsIn conclusion our results revealed no association between CCR2V64Il polymorphism and susceptibility to migraine and also headache severity in the Iranian population.

Indexed as

Polymorphism, Single NucleotideAdultAllelesCase-Control StudiesDNA Mutational AnalysisFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansIranMaleMigraine without AuraReceptors, CCR2Severity of Illness IndexSocioeconomic FactorsCCR2 protein, humanReceptors, CCR2

Identifiers

PMID24453913
PMCPMC3886219
OpenAlexW2021036796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.