Evidence map›Paper›PMID 24453753›Full record

ArticleInternational journal of MS care2012

Differentiation of neuromyelitis optica from multiple sclerosis on spinal magnetic resonance imaging.

Saurabh Lalan, Majid Khan, Bruce Schlakman, Alan Penman, Joseph Gatlin, Robert Herndon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of MS care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  5. Influence ofJournal of clinical medicine · 2024
    Article
  6. Comparison of OX40 expression in patients with multiple sclerosis and neuromyelitis optica as an approach to diagnosis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saurabh LalanDepartments of Neurology (SL, MK, RH), Radiology (MK, BS, JG), and Geriatrics and Biostatistics (AP), University of Mississippi Medical Center, Jackson, MS, USA; and Department of Neurology, Louisiana State University, New Orleans, LA, USA (SL).
Majid KhanDepartments of Neurology (SL, MK, RH), Radiology (MK, BS, JG), and Geriatrics and Biostatistics (AP), University of Mississippi Medical Center, Jackson, MS, USA; and Department of Neurology, Louisiana State University, New Orleans, LA, USA (SL).
Bruce SchlakmanDepartments of Neurology (SL, MK, RH), Radiology (MK, BS, JG), and Geriatrics and Biostatistics (AP), University of Mississippi Medical Center, Jackson, MS, USA; and Department of Neurology, Louisiana State University, New Orleans, LA, USA (SL).
Alan PenmanDepartments of Neurology (SL, MK, RH), Radiology (MK, BS, JG), and Geriatrics and Biostatistics (AP), University of Mississippi Medical Center, Jackson, MS, USA; and Department of Neurology, Louisiana State University, New Orleans, LA, USA (SL).
Joseph GatlinDepartments of Neurology (SL, MK, RH), Radiology (MK, BS, JG), and Geriatrics and Biostatistics (AP), University of Mississippi Medical Center, Jackson, MS, USA; and Department of Neurology, Louisiana State University, New Orleans, LA, USA (SL).
Robert HerndonDepartments of Neurology (SL, MK, RH), Radiology (MK, BS, JG), and Geriatrics and Biostatistics (AP), University of Mississippi Medical Center, Jackson, MS, USA; and Department of Neurology, Louisiana State University, New Orleans, LA, USA (SL).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to examine the accuracy of magnetic resonance imaging (MRI)-based diagnosis of neuromyelitis optica (NMO) versus multiple sclerosis (MS), we performed a retrospective, rater-blinded review of 29 cases of NMO and 30 cases of MS using the criteria of long (more than three vertebral levels), continuous lesions with a central cord location for NMO and more peripheral and patchy lesions for MS. Using these criteria, two raters were able to distinguish the two conditions with a good degree of confidence, particularly when the imaging was performed at the time of an acute cord attack. The sensitivity and specificity for diagnosis of NMO were 86.2% and 93.3%, respectively, for Rater A and 96.4% and 78.6%, respectively, for Rater B, with a kappa value of 0.72. Thus there are significant differences in lesion characteristics that allow the distinction on spinal cord imaging between MS and NMO with a moderately high degree of confidence. The location of the lesion as evident on MRI of the spine can be regarded as a distinguishing diagnostic feature between MS and NMO.

Identifiers

PMID24453753
PMCPMC3882989

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.