ArticleArchaea (Vancouver, B.C.)2013
Archaeal production of polyhydroxyalkanoate (PHA) co- and terpolyesters from biodiesel industry-derived by-products.
Article in Archaea (Vancouver, B.C.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 203 citations in OpenAlex.
- Article
- Insights into transcriptional expression and putative functions of multiple polyhydroxyalkanoate synthase paralogs in Haloferax mediterranei.FEMS microbiology letters · 2026Article
- Microbial conversion of biodiesel waste for carotenoid production.Frontiers in bioengineering and biotechnology · 2026Article
- Identification and Mitigation of Inhibitory Substances Contained in High-Salinity Crude Glycerol Generated from Biodiesel Production for Polyhydroxyalkanoate Synthesis byACS sustainable chemistry & engineering · 2025Article
- Advanced Strategies for Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production: PHA Synthase Homologous Overexpression in the ExtremophileMarine drugs · 2025Article
- Materials designed to degrade: structure, properties, processing, and performance relationships in polyhydroxyalkanoate biopolymers.Polymer chemistry · 2025Review
- Comparative genomics of the highly halophilic Haloferacaceae.Scientific reports · 2024Article
- Production of Polyhydroxyalkanoates for Biodegradable Food Packaging Applications UsingFoods (Basel, Switzerland) · 2024Review
- Identification and characterization of a potential strain for the production of polyhydroxyalkanoate from glycerol.Frontiers in microbiology · 2024Article
- Biotransformation of d-Xylose-Rich Rice Husk Hydrolysate by a Rice Paddy Soil Bacterium,Biomolecules · 2023Article
- Continuous bioreactor production of polyhydroxyalkanoates inFrontiers in bioengineering and biotechnology · 2023Article
- Characterization of Polyhydroxybutyrate, PHB, Synthesized by Newly Isolated HaloarchaeaMolecules (Basel, Switzerland) · 2022Article
- Bioconversion of Plastic Waste Based on Mass Full Carbon Backbone Polymeric Materials to Value-Added Polyhydroxyalkanoates (PHAs).Bioengineering (Basel, Switzerland) · 2022Review
- Review
- A fermentation process for the production of poly(3-hydroxybutyrate) using waste cooking oil or waste fish oil as inexpensive carbon substrate.Biotechnology reports (Amsterdam, Netherlands) · 2022Article
- Study on the production of high 3HV content PHBVFrontiers in microbiology · 2022Article
- Extremophilic BacteriumFrontiers in bioengineering and biotechnology · 2022Article
- Current Advances towards 4-Hydroxybutyrate Containing Polyhydroxyalkanoates Production for Biomedical Applications.Molecules (Basel, Switzerland) · 2021Review
- Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux.Communications biology · 2021Article
- Haloarchaea as Cell Factories to Produce Bioplastics.Marine drugs · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The archaeon Haloferax mediterranei was selected for production of PHA co- and terpolyesters using inexpensive crude glycerol phase (CGP) from biodiesel production as carbon source. CGP was assessed by comparison with the application of pure glycerol. Applying pure glycerol, a copolyester with a molar fraction of 3-hydroxybutyrate (3HB) of 0.90 mol/mol and 3-hydroxyvalerate (3HV) of 0.10 mol/mol, was produced at a volumetric productivity of 0.12 g/Lh and an intracellular PHA content of 75.4 wt.-% in the sum of biomass protein plus PHA. Application of CGP resulted in the same polyester composition and volumetric productivity, indicating the feasibility of applying CGP as feedstock. Analysis of molar mass distribution revealed a weight average molar mass M w of 150 kDa and polydispersity P i of 2.1 for pure glycerol and 253 kDa and 2.7 for CGP, respectively; melting temperatures ranged between 130 and 140°C in both setups. Supplying γ -butyrolactone as 4-hydroxybutyrate (4HB) precursor resulted in a poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate-co-4-hydroxybutyrate] (PHBHV4HB) terpolyester containing 3HV (0.12 mol/mol) and 4HB (0.05 mol/mol) in the poly[(R)-3-hydroxybutyrate] (PHB) matrix; in addition, this process runs without sterilization of the bioreactor. The terpolyester displayed reduced melting (melting endotherms at 122 and 137°C) and glass transition temperature (2.5°C), increased molar mass (391 kDa), and a polydispersity similar to the copolyesters.
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Registered trials
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