ArticleActa ortopedica brasileira2013
Transdermal monosialoganglioside with laser in the treatment of spinal cord lesion in rats.
Article in Acta ortopedica brasileira, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review.BMC neurology · 2024Pooled it
- The effect of low-level laser therapy on pathophysiology and locomotor recovery after traumatic spinal cord injuries: a systematic review and meta-analysis.Lasers in medical science · 2022Pooled it
- Glutathione effect on functional and histological recovery after spinal cord injury in rats.Clinics (Sao Paulo, Brazil) · 2024Article
- Transdermal administration of melatonin coupled to cryopass laser treatment as noninvasive therapy for prostate cancer.Drug delivery · 2017Article
- GM1 Ganglioside: Past Studies and Future Potential.Molecular neurobiology · 2016Review
- Neuroprotective effect of epidural hypothermia after spinal cord lesion in rats.Clinics (Sao Paulo, Brazil) · 2014Article
- Article
- THE EFFECT OF MONOSIALOGANGLYOSIDE (GM-1) ADMINISTRATION IN SPINAL CORD INJURY.Acta ortopedica brasileiraArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the effects of monosialoganglioside (GM1) administered transdermally with laser in the recovery of spinal cord injury in rats.
methodsForty male Wistar rats underwent spinal cord contusion using the NYU Impactor. In Group 1, the rats received 0,2 ml of saline intraperitoneally daily; in Group 2, GM1 was administered intraperitoneally at a concentration of 30 mg/kg per day; in Group 3, rats were treated daily with laser at low temperature on the skin, and in Group 4, the daily laser session also contained GM1. All the groups were treated for 42 days. The animals were evaluated by the Basso, Baettie and Bresnahan (BBB) functional scale on days 7, 14, 21, 28, 35 and 42 after the injury, and by histopathology and motor evoked potential after 42 days of injury.
resultsThe animals in Group 4 had higher BBB scores compared with the other groups. There were no differences between the groups, or in the comparisons over time. Histological evaluation showed no differences, and no differences were found in the motor evoked potential tests either.
conclusionGM1 associated with the use of low-temperature laser shows no superior functional, neurological or histological results in the treatment of spinal cord lesions in rats. Evidence Level I, Experimental, Controlled, Animal Study.
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