ArticleMediators of inflammation2013
Marked independent relationship between circulating interleukin-6 concentrations and endothelial activation in rheumatoid arthritis.
Article in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Management of a Patient with Cardiovascular Disease Should Include Assessment of Primary and Secondary Immunodeficiencies: Part 2-Secondary Immunodeficiencies.Healthcare (Basel, Switzerland) · 2024Review
- Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis.Frontiers in molecular biosciences · 2022Article
- Points to consider in cardiovascular disease risk management among patients with rheumatoid arthritis living in South Africa, an unequal middle income country.BMC rheumatology · 2020Article
- Systemic Inflammatory Response and Atherosclerosis: The Paradigm of Chronic Inflammatory Rheumatic Diseases.International journal of molecular sciences · 2018Review
- Disease severity impacts the relationship of apelin with arterial function in patients with rheumatoid arthritis.Clinical rheumatology · 2018Article
- Perioperative Management of Patients with Inflammatory Rheumatic Diseases Undergoing Major Orthopaedic Surgery: A Practical Overview.Advances in therapy · 2018Review
- Preserved cardiorespiratory function and NT-proBNP levels before and during exercise in patients with recent onset of rheumatoid arthritis: the clinical challenge of stratifying the patient cardiovascular risks.Rheumatology international · 2017Article
- Urinary albumin excretion is increased in patients with rheumatoid arthritis and associated with arterial stiffness.The Journal of rheumatology · 2015Article
- Angiotensin II in inflammation, immunity and rheumatoid arthritis.Clinical and experimental immunology · 2015Review
- Postoperative risk of venous thromboembolism in rheumatic disease patients.Current rheumatology reports · 2015Review
- Enhanced cardiovascular risk in rheumatoid arthritis: elucidation, assessment, and management.BioMed research international · 2015Article
- Assessment of the body composition and parameters of the cardiovascular risk in juvenile idiopathic arthritis.BioMed research international · 2015Article
- Retinol binding protein 4 concentrations relate to enhanced atherosclerosis in obese patients with rheumatoid arthritis.PloS one · 2014Article
- Article
- Cardiovascular disease risk amongst African black patients with rheumatoid arthritis: the need for population specific stratification.BioMed research international · 2014Review
- Adiponectin and atherosclerosis in rheumatoid arthritis.Mediators of inflammation · 2014Article
- Towards the elucidation of the true impact of adipocytokines on cardiovascular risk in rheumatoid arthritis.Arthritis research & therapy · 2013Article
- Rheumatoid arthritis and risk of cardiovascular disease.Cardiovascular journal of AfricaReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
We examined the potential impact of conventional compared with nonconventional cardiovascular risk factors including interleukin-6 levels on endothelial activation in RA. Circulating soluble E-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 concentrations were measured in 217 African patients (112 black and 105 white) with RA. In comprehensive confounder adjusted mixed regression models, 5 conventional and 4 nonconventional cardiovascular risk factors were associated (P = 0.05 to <0.0001) with endothelial activation. Interleukin-6 was the only risk factor related to each endothelial activation molecule and independently contributed by 18% and significantly more than other risk factors to the variation in overall endothelial activation as estimated by an SD (z) score of endothelial activation molecule concentrations. The independent interleukin-6-overall endothelial activation relationships were reproduced in various subgroups. Interleukin-6 concentrations relate consistently, markedly, and to a larger extent than other cardiovascular risk factors to endothelial activation in RA. Assessment of interleukin-6 concentrations may enhance cardiovascular risk stratification in RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.