Evidence map›Paper›PMID 24453420›Full record

ArticleMediators of inflammation2013

Ethyl pyruvate ameliorates hepatic ischemia-reperfusion injury by inhibiting intrinsic pathway of apoptosis and autophagy.

Miao Shen, Jie Lu, Weiqi Dai, Fan Wang, Ling Xu, Kan Chen, Lei He, Ping Cheng, Yan Zhang, Chengfen Wang and 6 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. The Role of Hydrogen Sulfide Regulation of Autophagy in Liver Disorders.International journal of molecular sciences · 2022
    Review
  6. Ethyl pyruvate, a versatile protector in inflammation and autoimmunity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms.Liver international : official journal of the International Association for the Study of the Liver · 2019
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Miao ShenDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Jie LuDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Weiqi DaiDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Fan WangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Ling XuDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Kan ChenDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Lei HeDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Ping ChengDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Yan ZhangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Chengfen WangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Dong WuDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Jing YangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Rong ZhuDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Huawei ZhangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Yinqun ZhouDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Chuanyong GuoDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Tongji University · CNShanghai Tenth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatic ischemia-reperfusion (I/R) injury is a pivotal clinical problem occurring in many clinical conditions such as transplantation, trauma, and hepatic failure after hemorrhagic shock. Apoptosis and autophagy have been shown to contribute to cell death in hepatic I/R injury. Ethyl pyruvate, a stable and simple lipophilic ester, has been shown to have anti-inflammatory properties. In this study, the purpose is to explore both the effect of ethyl pyruvate on hepatic I/R injury and regulation of intrinsic pathway of apoptosis and autophagy.

methodsThree doses of ethyl pyruvate (20 mg/kg, 40 mg/kg, and 80 mg/kg) were administered 1 h before a model of segmental (70%) hepatic warm ischemia was established in Balb/c mice. All serum and liver tissues were obtained at three different time points (4 h, 8 h, and 16 h).

resultsAlanine aminotransferase (ALT), aspartate aminotransferase (AST), and pathological features were significantly ameliorated by ethyl pyruvate (80 mg/kg). The expression of Bcl-2, Bax, Beclin-1, and LC3, which play an important role in the regulation of intrinsic pathway of apoptosis and autophagy, was also obviously decreased by ethyl pyruvate (80 mg/kg). Furthermore, ethyl pyruvate inhibited the HMGB1/TLR4/ NF-κb axis and the release of cytokines (TNF-α and IL-6).

conclusionOur results showed that ethyl pyruvate might attenuate to hepatic I/R injury by inhibiting intrinsic pathway of apoptosis and autophagy, mediated partly through downregulation of HMGB1/TLR4/ NF-κb axis and the competitive interaction with Beclin-1 of HMGB1.

Indexed as

AnimalsApoptosisApoptosis Regulatory ProteinsAutophagybcl-2-Associated X ProteinBeclin-1HMGB1 ProteinInterleukin-6 InhibitorsMaleMiceMice, Inbred BALB CMicrotubule-Associated ProteinsNF-kappa BProto-Oncogene Proteins c-bcl-2PyruvatesReperfusion InjuryApoptosis Regulatory ProteinsBax protein, mousebcl-2-Associated X ProteinBeclin-1Becn1 protein, mouseethyl pyruvateHMGB1 ProteinHMGB1 protein, mouseInterleukin-6 InhibitorsMap1lc3b protein, mouseMicrotubule-Associated ProteinsNF-kappa BProto-Oncogene Proteins c-bcl-2PyruvatesTumor Necrosis Factor-alpha

Identifiers

PMID24453420
PMCPMC3886226
OpenAlexW2094211752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.