ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Short-term synaptic depression is topographically distributed in the cochlear nucleus of the chicken.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Formation, Organization, and Maintenance of Synaptic Vesicle Pools: From Molecules to Structure and Dynamics.Advances in neurobiology · 2026Review
- Power-law adaptation in the presynaptic vesicle cycle.Communications biology · 2025Article
- Modulating Neuromorphic Behavior of Organic Synaptic Electrolyte-Gated Transistors Through Microstructure Engineering and Potential Applications.ACS applied materials & interfaces · 2024Article
- A neuron model with unbalanced synaptic weights explains the asymmetric effects of anaesthesia on the auditory cortex.PLoS biology · 2023Article
- Tonotopic differentiation of presynaptic neurotransmitter-releasing machinery in the auditory brainstem during the prehearing period and its selective deficits in Fmr1 knockout mice.The Journal of comparative neurology · 2022Article
- Expression and Neurotransmitter Association of the Synaptic Calcium Sensor Synaptotagmin in the Avian Auditory Brain Stem.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Tonotopic Specializations in Number, Size, and Reversal Potential of GABAergic Inputs Fine-Tune Temporal Coding at Avian Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Endogenous Cholinergic Signaling Modulates Sound-Evoked Responses of the Medial Nucleus of the Trapezoid Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Excitatory-Inhibitory Synaptic Coupling in Avian Nucleus Magnocellularis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Dynamics of synaptic extracellular field potentials in the nucleus laminaris of the barn owl.Journal of neurophysiology · 2019Article
- Intrinsic and Synaptic Dynamics Contribute to Adaptation in the Core of the Avian Central Nucleus of the Inferior Colliculus.Frontiers in neural circuits · 2019Article
- Postsynaptic FMRP Regulates SynaptogenesisThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Phase-locking and bistability in neuronal networks with synaptic depression.Physica D. Nonlinear phenomena · 2018Article
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Functional roles of short-term synaptic plasticity with an emphasis on inhibition.Current opinion in neurobiology · 2017Review
- Tonotopic Optimization for Temporal Processing in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Target-specific regulation of presynaptic release properties at auditory nerve terminals in the avian cochlear nucleus.Journal of neurophysiology · 2016Article
- Factors Influencing Short-term Synaptic Plasticity in the Avian Cochlear Nucleus Magnocellularis.Journal of experimental neuroscience · 2015Article
- Metabotropic glutamate receptors in auditory processing.Neuroscience · 2014Review
- Neuronal specializations for the processing of interaural difference cues in the chick.Frontiers in neural circuits · 2014Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the auditory system, sounds are processed in parallel frequency-tuned circuits, beginning in the cochlea. Activity of auditory nerve fibers reflects this frequency-specific topographic pattern, known as tonotopy, and imparts frequency tuning onto their postsynaptic target neurons in the cochlear nucleus. In birds, cochlear nucleus magnocellularis (NM) neurons encode the temporal properties of acoustic stimuli by "locking" discharges to a particular phase of the input signal. Physiological specializations exist in gradients corresponding to the tonotopic axis in NM that reflect the characteristic frequency (CF) of their auditory nerve fiber inputs. One feature of NM neurons that has not been investigated across the tonotopic axis is short-term synaptic plasticity. NM offers a rather homogeneous population of neurons with a distinct topographical distribution of synaptic properties that is ideal for the investigation of specialized synaptic plasticity. Here we demonstrate for the first time that short-term synaptic depression (STD) is expressed topographically, where unitary high CF synapses are more robust with repeated stimulation. Correspondingly, high CF synapses drive spiking more reliably than their low CF counterparts. We show that postsynaptic AMPA receptor desensitization does not contribute to the observed difference in STD. Further, rate of recovery from depression, a presynaptic property, does not differ tonotopically. Rather, we show that another presynaptic feature, readily releasable pool (RRP) size, is tonotopically distributed and inversely correlated with vesicle release probability. Mathematical model results demonstrate that these properties of vesicle dynamics are sufficient to explain the observed tonotopic distribution of STD.
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