ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Large-scale somatotopic refinement via functional synapse elimination in the sensory thalamus of developing mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Adolescent stress remodels synapses in the sensory thalamus and impairs tactile discrimination in mice.Communications biology · 2025Article
- Article
- Synaptic transmission is dispensable for selecting the winner input but is crucial for the subsequent events of synapse elimination.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Purkinje cell ablation and Purkinje cell-specific deletion of Tsc1 in the developing cerebellum strengthen cerebellothalamic synapses.The Journal of physiology · 2024Article
- Developmental Impairments of Synaptic Refinement in the Thalamus of a Mouse Model of Fragile X Syndrome.Neuroscience bulletin · 2024Article
- Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice.The Journal of experimental medicine · 2023Article
- Fluorochromized tyramide-glucose oxidase as a multiplex fluorescent tyramide signal amplification system for histochemical analysis.Scientific reports · 2022Article
- Electrophysiological and anatomical characterization of synaptic remodeling in the mouse whisker thalamus.STAR protocols · 2021Article
- Distinct functional developments of surviving and eliminated presynaptic terminals.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Engulfed by Glia: Glial Pruning in Development, Function, and Injury across Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development.FEBS open bio · 2020Article
- Article
- Development of tactile sensory circuits in the CNS.Current opinion in neurobiology · 2018Review
- Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity.Cell reports · 2018Article
- Functional Topography and Development of Inhibitory Reticulothalamic Barreloid Projections.Frontiers in neuroanatomy · 2018Article
- A method package for electrophysiological evaluation of reconstructed or regenerated facial nerves in rodents.MethodsX · 2018Article
- Experience-dependent MeCP2 expression in the excitatory cells of mouse visual thalamus.PloS one · 2018Article
- Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons.Nature communications · 2017Article
- Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats.Scientific reports · 2017Article
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional synapse elimination and strengthening are crucial developmental processes in the formation of precise neuronal circuits in the somatosensory system, but the underlying alterations in topographical organization are not yet fully understood. To address this issue, we generated transgenic mice in which afferent fibers originating from the whisker-related brain region, called the maxillary principal trigeminal nucleus (PrV2), were selectively visualized with genetically expressed fluorescent protein. We found that functional synapse elimination drove and established large-scale somatotopic refinement even after the thalamic barreloid architecture was formed. Before functional synapse elimination, the whisker sensory thalamus was innervated by afferent fibers not only from the PrV2, but also from the brainstem nuclei representing other body parts. Most notably, only afferent fibers from PrV2 onto a whisker sensory thalamic neuron selectively survived and were strengthened, whereas other afferent fibers were preferentially eliminated via their functional synapse elimination. This large-scale somatotopic refinement was at least partially dependent on somatosensory experience. These novel results uncovered a previously unrecognized role of developmental synapse elimination in the large-scale, instead of the fine-scale, somatotopic refinement even after the initial segregation of the barreloid map.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.