ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Hippocampal pyramidal neurons switch from a multipolar migration mode to a novel "climbing" migration mode during development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Spatiotemporal coordination of Slit-Robo repulsion and neurturin-Gfrα attraction guides multipolar migration during retinal lamination.Cell reports · 2026Article
- In Utero Electroporation Uncovers an Early-Differentiating Subset of Dentate Gyrus Progenitors.Cellular and molecular neurobiology · 2025Article
- KLF7 orchestrates hippocampal development through neurogenesis and Draxin-mediated neuronal migration.Development (Cambridge, England) · 2025Article
- Cadherin-6 controls neuronal migration during mouse neocortical development via an integrin-mediated pathway.The FEBS journal · 2025Article
- The Aryl Hydrocarbon Receptor in Neurotoxicity: An Intermediator Between Dioxins and Neurons in the Brain.Toxics · 2025Review
- Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies.Pediatric research · 2024Review
- Histone methyltransferase SETD2 is required for proper hippocampal lamination and neuronal maturation.Molecular biology of the cell · 2024Article
- Brain Sample Preparation After Performing in Utero Electroporation to Proliferating and Differentiated Cells in the Developing Mouse Neocortex.Methods in molecular biology (Clifton, N.J.) · 2024Article
- HeterozygouseNeuro · 2023Article
- A Unique "Reversed" Migration of Neurons in the Developing Claustrum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex.Nature communications · 2022Article
- Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis.Nature neuroscience · 2022Article
- Regulatory Effects of Gradient Microtopographies on Synapse Formation and Neurite Growth in Hippocampal Neurons.Journal of micromechanics and microengineering : structures, devices, and systems · 2022Article
- Step by step: cells with multiple functions in cortical circuit assembly.Nature reviews. Neuroscience · 2022Review
- Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina.eLife · 2022Article
- Development of the gonadotropin-releasing hormone system.Journal of neuroendocrinology · 2022Review
- Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development.Cell reports · 2022Article
- Synaptic communication mediates the assembly of a self-organizing circuit that controls reproduction.Science advances · 2021Article
- Enhanced FGFR3 activity in postmitotic principal neurons during brain development results in cortical dysplasia and axonal tract abnormality.Scientific reports · 2020Article
- Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation.Biomolecules · 2020Review
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6 authors.
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Abstract
The hippocampus plays important roles in brain functions. Despite the importance of hippocampal functions, recent analyses of neuronal migration have mainly been performed on the cerebral neocortex, and the cellular mechanisms responsible for the formation of the hippocampus are not yet completely understood. Moreover, why a prolonged time is required for hippocampal neurons to complete their migration has been unexplainable for several decades. We analyzed the migratory profile of neurons in the developing mouse hippocampal CA1 region and found that the hippocampal pyramidal neurons generated near the ventricle became postmitotic multipolar cells and accumulated in the multipolar cell accumulation zone (MAZ) in the late stage of development. The hippocampal neurons passed through the pyramidal layer by a unique mode of migration. Their leading processes were highly branched and made contact with many radial fibers. Time-lapse imaging revealed that the migrating cells changed their scaffolds from the original radial fibers to other radial fibers, and as a result they proceed in a zigzag manner, with long intervals. The migrating cells in the hippocampus reminded us of "rock climbers" that instead of using their hands to pull up their bodies were using their leading processes to pull up their cell bodies. Because this mode of migration had never been described, we called it the "climbing" mode. The change from the "climbing" mode in the hippocampus to the "locomotion" mode in the neocortex may have contributed to the brain expansion during evolution.
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