ArticleHuman brain mapping2014
Progression of brain atrophy in the early stages of Parkinson's disease: a longitudinal tensor-based morphometry study in de novo patients without cognitive impairment.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 98 citations in OpenAlex.
- Aerobic Exercise Alters Brain Function and Structure in Parkinson's Disease: A Randomized Controlled Trial.Annals of neurology · 2022Trial
- Linking cortical morphology and neurophysiological dynamics in Parkinson's disease.Scientific reports · 2026Article
- Early functional network alterations predict motor and cognitive decline in parkinson's disease.Scientific reports · 2025Article
- Linking Cortical Morphology and Neurophysiological Dynamics in Parkinson's Disease.Research square · 2025Article
- Understanding individual neurodegenerative progression in Parkinson's disease through normative modelling.Scientific reports · 2025Article
- Multivariate Associations Between Neurophysiological Activity and Sensory Motor Cortical Morphometry in Parkinson's Disease.bioRxiv : the preprint server for biology · 2025Article
- The disease-specific structural pattern in Parkinson's disease and its cortical characteristics associated with gene function: a 7-Tesla MRI study.Journal of neurology · 2025Article
- Changes in Action Tremor in Parkinson's Disease over Time: Clinical and Neuroimaging Correlates.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Cortical microstructural alterations in different stages of Parkinson's disease.Brain imaging and behavior · 2024Article
- Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's disease.Translational psychiatry · 2024Article
- Understanding the role of cerebellum in early Parkinson's disease: a structural and functional MRI study.NPJ Parkinson's disease · 2024Article
- The effect of dopamine replacement therapy on cortical structure in Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Exploiting macro- and micro-structural brain changes for improved Parkinson's disease classification from MRI data.NPJ Parkinson's disease · 2024Article
- Learning Phenotypic Associations for Parkinson's Disease with Longitudinal Clinical Records.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2024Article
- How should we be using biomarkers in trials of disease modification in Parkinson's disease?Brain : a journal of neurology · 2023Article
- White and gray matter alterations in de novo PD patients: which matter most?Journal of neurology · 2023Article
- Beyond shallow feelings of complex affect: Non-motor correlates of subjective emotional experience in Parkinson's disease.PloS one · 2023Article
- Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease.Neurology and therapy · 2022Article
- Basal ganglia atrophy-associated causal structural network degeneration in Parkinson's disease.Human brain mapping · 2022Article
- Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson's disease.NPJ Parkinson's disease · 2022Review
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of brain atrophy and its progression in early Parkinson's disease (PD) are still a matter of debate, particularly in patients without cognitive impairment. The aim of this longitudinal study was to assess whether PD patients who remain cognitively intact develop progressive atrophic changes in the early stages of the disease. For this purpose, we employed high-resolution T1-weighted MR imaging to compare 22 drug-naïve de novo PD patients without cognitive impairment to 17 age-matched control subjects, both at baseline and at three-year follow-up. We used tensor-based morphometry to explore the presence of atrophic changes at baseline and to compute yearly atrophy rates, after which we performed voxel-wise group comparisons using threshold-free cluster enhancement. At baseline, we did not observe significant differences in regional atrophy in PD patients with respect to control subjects. In contrast, PD patients showed significantly higher yearly atrophy rates in the prefrontal cortex, anterior cingulum, caudate nucleus, and thalamus when compared to control subjects. Our results indicate that even cognitively preserved PD patients show progressive cortical and subcortical atrophic changes in regions related to cognitive functions and that these changes are already detectable in the early stages of the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.