ArticleHuman brain mapping2014
Neurodevelopmental alterations of large-scale structural networks in children with new-onset epilepsy.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Progressive Changes in Brain Morphology in People With Idiopathic Generalized Epilepsy.Neurology · 2026Article
- Brain connectome from neuronal morphology.Network neuroscience (Cambridge, Mass.) · 2025Article
- How the intrinsic functional connectivity patterns of the semantic network support semantic processing.Brain imaging and behavior · 2024Article
- Abnormal Topological Organization of Structural Covariance Networks in Patients with Temporal Lobe Epilepsy Comorbid Sleep Disorder.Brain sciences · 2023Article
- Cognitive function and the longitudinal hippocampal axis in mesial temporal sclerosis.Epilepsy & behavior : E&B · 2023Article
- Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression.Nature communications · 2022Article
- Cognition, Behavior, and Psychosocial Effects of Seizures in the Developing Brain.Current topics in behavioral neurosciences · 2022Article
- Network analysis of prospective brain development in youth with benign epilepsy with centrotemporal spikes and its relationship to cognition.Epilepsia · 2019Article
- Microstructural and functional gradients are increasingly dissociated in transmodal cortices.PLoS biology · 2019Article
- Alteration of the anatomical covariance network after corpus callosotomy in pediatric intractable epilepsy.PloS one · 2019Article
- Progressive dissociation of cortical and subcortical network development in children with new-onset juvenile myoclonic epilepsy.Epilepsia · 2018Article
- Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes.Frontiers in neuroanatomy · 2018Review
- Development of Structural Covariance From Childhood to Adolescence: A Longitudinal Study in 22q11.2DS.Frontiers in neuroscience · 2018Article
- Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study.World journal of radiology · 2017Article
- Brain structure and organization five decades after childhood onset epilepsy.Human brain mapping · 2017Article
- Graph theory and cognition: A complementary avenue for examining neuropsychological status in epilepsy.Epilepsy & behavior : E&B · 2016Review
- Disruptions in cortico-subcortical covariance networks associated with anxiety in new-onset childhood epilepsy.NeuroImage. Clinical · 2016Article
- Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study.Epilepsy research · 2015Article
- Mapping the landscape of cognitive development in children with epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2015Article
- Quantitative MRI in refractory temporal lobe epilepsy: relationship with surgical outcomes.Quantitative imaging in medicine and surgery · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Recent neuroimaging and behavioral studies have revealed that children with new onset epilepsy already exhibit brain structural abnormalities and cognitive impairment. How the organization of large-scale brain structural networks is altered near the time of seizure onset and whether network changes are related to cognitive performances remain unclear. Recent studies also suggest that regional brain volume covariance reflects synchronized brain developmental changes. Here, we test the hypothesis that epilepsy during early-life is associated with abnormalities in brain network organization and cognition. We used graph theory to study structural brain networks based on regional volume covariance in 39 children with new-onset seizures and 28 healthy controls. Children with new-onset epilepsy showed a suboptimal topological structural organization with enhanced network segregation and reduced global integration compared with controls. At the regional level, structural reorganization was evident with redistributed nodes from the posterior to more anterior head regions. The epileptic brain network was more vulnerable to targeted but not random attacks. Finally, a subgroup of children with epilepsy, namely those with lower IQ and poorer executive function, had a reduced balance between network segregation and integration. Taken together, the findings suggest that the neurodevelopmental impact of new onset childhood epilepsies alters large-scale brain networks, resulting in greater vulnerability to network failure and cognitive impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.