ReviewPediatric cardiology2014
Potential effects of environmental chemical contamination in congenital heart disease.
Review in Pediatric cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Exposure to Endocrine-Disrupting Chemicals and Congenital Heart Diseases: The Pooled Results Based on the Current Evidence.Pediatric cardiology · 2025Pooled it
- Associations of maternal upper respiratory tract infection/influenza during early pregnancy with congenital heart disease in offspring: evidence from a case-control study and meta-analysis.BMC cardiovascular disorders · 2019Pooled it
- Prenatal computed tomography (CT) and risk of congenital heart disease and cerebral palsy: A nationwide mother-child paired cohort study.BMC medicine · 2026Article
- Transthoracic echocardiographic assessment of ventricular function in functional single ventricle: a comprehensive review.Cardiovascular ultrasound · 2025Review
- Identification and analysis of inflammation-related biomarkers in tetralogy of Fallot.Translational pediatrics · 2024Article
- Pulmonary vascular disease, environmental pollution, and climate change.Pulmonary circulation · 2024Review
- Environmental Signals.Advances in experimental medicine and biology · 2024Article
- Epigenetic Evaluation of theCells · 2023Article
- Early prenatal exposure to air pollutants and congenital heart disease: a nested case-control study.Environmental health and preventive medicine · 2023Article
- Association between Maternal Selenium Exposure and Congenital Heart Defects in Offspring: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2022Review
- Association between maternal smoke exposure and congenital heart defects from a case-control study in China.Scientific reports · 2022Article
- Maternal Viral Infection in Early Pregnancy and Risk of Congenital Heart Disease in Offspring: A Prospective Cohort Study in Central China.Clinical epidemiology · 2022Article
- Parental risk factors associated with congenital heart disease in a Thai population: multivariable analysis.Asian biomedicine : research, reviews and news · 2021Article
- Children's Environmental Health: A Systems Approach for Anticipating Impacts from Chemicals.International journal of environmental research and public health · 2020Review
- Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses.Scientific reports · 2020Article
- Maternal occupational exposure and congenital heart defects in offspring.Scandinavian journal of work, environment & health · 2020Article
- Article
- Prevalence of Congenital Anomalies in the Japan Environment and Children's Study.Journal of epidemiology · 2019Article
- The Role of Non-Coding RNA in Congenital Heart Diseases.Journal of cardiovascular development and disease · 2019Review
- Early life environment and social determinants of cardiac health in children with congenital heart disease.Paediatrics & child health · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is compelling evidence that prenatal exposures to environmental xenobiotics adversely affect human development and childhood. Among all birth defects, congenital heart disease (CHD) is the most prevalent of all congenital malformations and remains the leading cause of death. It has been estimated that in most cases the causes of heart defects remain unknown, while a growing number of studies have indicated the potential role of environmental agents as risk factors in CHD occurrence. In particular, maternal exposure to chemicals during the first trimester of pregnancy represents the most critical window of exposure for CHD. Specific classes of xenobiotics (e.g. organochlorine pesticides, organic solvents, air pollutants) have been identified as potential risk factors for CHD. Nonetheless, the knowledge gained is currently still incomplete as a consequence of the frequent heterogeneity of the methods applied and the difficulty in estimating the net effect of environmental pollution on the pregnant mother. The presence of multiple sources of pollution, both indoor and outdoor, together with individual lifestyle factors, may represent a further confounding element for association with the disease. A future new approach for research should probably focus on individual measurements of professional, domestic, and urban exposure to physical and chemical pollutants in order to accurately retrace the environmental exposure of parents of affected offspring during the pre-conceptional and pregnancy periods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.