ArticleDigestive diseases and sciences2014
The protective role of interleukin-11 against neutron radiation injury in mouse intestines via MEK/ERK and PI3K/Akt dependent pathways.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Contribution of immune cells and cytokines to radiation-induced injury: the key roles and potential targets.Frontiers in immunology · 2026Review
- TMT-based proteomic analysis of radiation lung injury in rats.Clinical proteomics · 2024Article
- NLRP1 restricts porcine deltacoronavirus infection via IL-11 inhibiting the phosphorylation of the ERK signaling pathway.Journal of virology · 2024Article
- Therapeutic mechanism of Liangxue-Guyuan-Yishen decoction on intestinal stem cells and tight junction proteins in gastrointestinal acute radiation syndrome rats.Journal of radiation research · 2023Article
- Effects of Therapeutic Platelet-Rich Plasma on Overactive Bladder via Modulating Hyaluronan Synthesis in Ovariectomized Rat.International journal of molecular sciences · 2023Article
- Article
- The delayed effects of acute radiation exposure (DEARE): characteristics, mechanisms, animal models, and promising medical countermeasures.International journal of radiation biology · 2023Review
- Review
- Sox9-expressing cells promote regeneration after radiation-induced lung injury via the PI3K/AKT pathway.Stem cell research & therapy · 2021Article
- Colitis-induced IL11 promotes colon carcinogenesis.Carcinogenesis · 2021Article
- Polydatin Attenuates 14.1 MeV Neutron-Induced Injuries via Regulating the Apoptosis and Antioxidative Pathways and Improving the Hematopoiesis of Mice.Oxidative medicine and cellular longevity · 2020Article
- Antiviral activity of interleukin-11 as a response to porcine epidemic diarrhea virus infection.Veterinary research · 2019Article
- Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K/AKT signaling pathway.Stem cell research & therapy · 2019Article
- Developmental toxicity and apoptosis in zebrafish embryos induced by low-dose γ-ray irradiation.Environmental science and pollution research international · 2019Article
- IL-11 prevents IFN-γ-induced hepatocyte death through selective downregulation of IFN-γ/STAT1 signaling and ROS scavenging.PloS one · 2019Article
- A new and important relationship between miRNA-147a and PDPK1 in radiotherapy.Journal of cellular biochemistry · 2018Article
- STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Review
- Intestinal dendritic cells change in number in fulminant hepatic failure.World journal of gastroenterology · 2015Article
- Toward development of interleukin-11 as a medical countermeasure for use in radiological/nuclear emergencies.Digestive diseases and sciences · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeutron irradiation (IR) has been proven to cause more serious damage than gamma IR. Preventing and curing neutron IR damage remains an urgent issue.
aimsThe objective of this study was to investigate the radioprotective effects of IL-11 against neutron IR-induced damage in small intestine of mice.
methodsMice were exposed to 3-Gy neutron IR whole body and then treated with 500 μg/kg interleukin-11 (IL-11) intraperitoneally every day. Mice were observed at various time-points over 1-5 days after IR. IEC-6 cells were exposed to 4 Gy neutron IR, and 100 ng/mL rhIL-11 was added to culture medium. Cell proliferation activity was estimated by MTT assay and rates of apoptosis were estimated by flow cytometry.
resultsIL-11 slightly alleviated the incidence of diarrhea in the mice and promoted intestinal epithelia regeneration. In the in vitro study, neutron IR activated extracellular signal-regulated kinase (ERK)1/2 phosphorylation in intestinal epithelial cells constitutively, which was initially suppressed and then activated later by IL-11. The MEK-specific inhibitor U0126 could antagonize the positive effect of IL-11 on cell growth. Phosphatidylinositol 3-kinase (PI3K)/Akt pathway activation was suppressed after neutron IR, but could be triggered by IL-11 to protect the cells. The PI3K inhibitor LY294002 suppressed the positive effect of IL-11 on cell growth, and antagonized the protective effect of IL-11 against cell death after neutron IR.
conclusionIL-11 increases cell proliferation after neutron IR in MEK and PI3K-dependent signaling pathways, but protects cells against death only in the PI3K-dependent signaling pathway.
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