ArticleNucleic acids research2014
A ribozyme that triphosphorylates RNA 5'-hydroxyl groups.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A ribozyme ligase that requires a 3' terminal phosphate on its RNA substrate.Nature communications · 2026Article
- The Exceptional Solubility of Cyclic Trimetaphosphate in the Presence of MgLife (Basel, Switzerland) · 2026Article
- Assembly of catalytic complexes from randomized oligonucleotides.Science advances · 2025Article
- Principles ofJournal of the Royal Society, Interface · 2025Article
- Nucleoside Analogs: A Review of Its Source and Separation Processes.Molecules (Basel, Switzerland) · 2023Review
- Peptide conjugates with polyaromatic hydrocarbons can benefit the activity of catalytic RNAs.Chemical science · 2023Article
- A ribozyme that uses lanthanides as cofactor.Nucleic acids research · 2023Article
- Minimizing amplification bias during reverse transcription for in vitro selections.RNA (New York, N.Y.) · 2023Article
- Building the uracil skeleton in primitive ponds at the origins of life: carbamoylation of aspartic acid.Scientific reports · 2022Article
- Prebiotic Chemistry: The Role of Trimetaphosphate in Prebiotic Chemical Evolution.Frontiers in chemistry · 2022Review
- A GTP-synthesizing ribozyme selected by metabolic coupling to an RNA polymerase ribozyme.Science advances · 2021Article
- Water/Oil Emulsions with Controlled Droplet Sizes forACS omega · 2021Article
- Encapsulation of ribozymes inside model protocells leads to faster evolutionary adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Prebiotically Plausible RNA Activation Compatible with Ribozyme-Catalyzed Ligation.Angewandte Chemie (International ed. in English) · 2021Article
- A combinatorial method to isolate short ribozymes from complex ribozyme libraries.Nucleic acids research · 2020Article
- Bacterial Phosphate Granules Contain Cyclic Polyphosphates: Evidence fromJournal of the American Chemical Society · 2020Article
- New Deoxyribozymes for the Native Ligation of RNA.Molecules (Basel, Switzerland) · 2020Article
- Systematic minimization of RNA ligase ribozyme through large-scale design-synthesis-sequence cycles.Nucleic acids research · 2019Article
- Polyanion-Assisted Ribozyme Catalysis Inside Complex Coacervates.ACS chemical biology · 2019Article
- Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response.The EMBO journal · 2018Article
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2 authors.
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Abstract
The RNA world hypothesis describes a stage in the early evolution of life in which RNA served as genome and as the only genome-encoded catalyst. To test whether RNA world organisms could have used cyclic trimetaphosphate as an energy source, we developed an in vitro selection strategy for isolating ribozymes that catalyze the triphosphorylation of RNA 5'-hydroxyl groups with trimetaphosphate. Several active sequences were isolated, and one ribozyme was analyzed in more detail. The ribozyme was truncated to 96 nt, while retaining full activity. It was converted to a trans-format and reacted with rates of 0.16 min(-1) under optimal conditions. The secondary structure appears to contain a four-helical junction motif. This study showed that ribozymes can use trimetaphosphate to triphosphorylate RNA 5'-hydroxyl groups and suggested that RNA world organisms could have used trimetaphosphate as their energy source.
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