ArticleAmerican journal of physiology. Renal physiology2014
Measurement of renal tissue oxygenation with blood oxygen level-dependent MRI and oxygen transit modeling.
Article in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Pooled it
- Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging: a prospective case control study.Critical care (London, England) · 2022Trial
- MRI-PHYSIOL-NIRS: an integrated platform to study kidney oxygenation.Communications engineering · 2026Article
- Hypoxic Preconditioning: An Underestimated Endogenous Protective Strategy?Biomolecules · 2026Review
- Magnetic Resonance Cartography of Renal Tubule Volume Fraction During Diuretic Intervention.Acta physiologica (Oxford, England) · 2025Article
- Magnetic resonance imaging of renal oxygenation.Nature reviews. Nephrology · 2025Review
- Multiparametric MRI: can we assess renal function differently?Clinical kidney journal · 2025Review
- Accurate exclusion of kidney regions affected by susceptibility artifact in blood oxygenation level-dependent (BOLD) images using deep-learning-based segmentation.Scientific reports · 2023Article
- Developing Strategies to Improve the Efficacy of CAR-T Therapy for Acute Myeloid Leukemia.Current treatment options in oncology · 2023Review
- Challenges and new technologies in adoptive cell therapy.Journal of hematology & oncology · 2023Review
- Year in Review 2022: Noteworthy Literature in Cardiac Anesthesiology.Seminars in cardiothoracic and vascular anesthesia · 2023Review
- Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours.Nature reviews. Clinical oncology · 2023Review
- A distinctive distribution of hypoxia-inducible factor-1α in cultured renal tubular cells with hypoperfusion simulated by coverslip placement.Physiological reports · 2021Article
- Pathophysiological Relevance of Renal Medullary Conditions on the Behaviour of Red Cells From Patients With Sickle Cell Anaemia.Frontiers in physiology · 2021Article
- MRI Mapping of the Blood Oxygenation Sensitive Parameter TMethods in molecular biology (Clifton, N.J.) · 2021Article
- Susceptibility weighted imaging (SWI) for evaluating renal dysfunction in type 2 diabetes mellitus: a preliminary study using SWI parameters and SWI-based texture features.Annals of translational medicine · 2020Article
- The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?Kidney international · 2020Review
- Peritubular Capillary Oxygen Consumption in Sepsis-Induced AKI: Multi-Parametric Photoacoustic Microscopy.Nephron · 2020Review
- The role of oxidative stress and hypoxia in renal disease.Kidney research and clinical practice · 2019Review
- Human renal response to furosemide: Simultaneous oxygenation and perfusion measurements in cortex and medulla.Acta physiologica (Oxford, England) · 2019Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Blood oxygen level-dependent (BOLD) MRI data of kidney, while indicative of tissue oxygenation level (Po2), is in fact influenced by multiple confounding factors, such as R2, perfusion, oxygen permeability, and hematocrit. We aim to explore the feasibility of extracting tissue Po2 from renal BOLD data. A method of two steps was proposed: first, a Monte Carlo simulation to estimate blood oxygen saturation (SHb) from BOLD signals, and second, an oxygen transit model to convert SHb to tissue Po2. The proposed method was calibrated and validated with 20 pigs (12 before and after furosemide injection) in which BOLD-derived tissue Po2 was compared with microprobe-measured values. The method was then applied to nine healthy human subjects (age: 25.7 ± 3.0 yr) in whom BOLD was performed before and after furosemide. For the 12 pigs before furosemide injection, the proposed model estimated renal tissue Po2 with errors of 2.3 ± 5.2 mmHg (5.8 ± 13.4%) in cortex and -0.1 ± 4.5 mmHg (1.7 ± 18.1%) in medulla, compared with microprobe measurements. After injection of furosemide, the estimation errors were 6.9 ± 3.9 mmHg (14.2 ± 8.4%) for cortex and 2.6 ± 4.0 mmHg (7.7 ± 11.5%) for medulla. In the human subjects, BOLD-derived medullary Po2 increased from 16.0 ± 4.9 mmHg (SHb: 31 ± 11%) at baseline to 26.2 ± 3.1 mmHg (SHb: 53 ± 6%) at 5 min after furosemide injection, while cortical Po2 did not change significantly at ∼58 mmHg (SHb: 92 ± 1%). Our proposed method, validated with a porcine model, appears promising for estimating tissue Po2 from renal BOLD MRI data in human subjects.
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