Observational studyPediatric research2014
Improvement in asthma control and inflammation in children undergoing adenotonsillectomy.
Observational study in Pediatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.Scientific reports · 2025Trial
- Profiling cellular heterogeneity in asthma with single cell multiparameter CyTOF.Journal of leukocyte biology · 2020Trial
- Differential effects of adenotonsillectomy on growth and asthma control in children with obstructive sleep apnea and varying body mass index: A prospective cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Sleep disorders in children with asthma.Pediatric pulmonology · 2022Review
- Adenotonsillectomy, bronchoscopy and bronchoalveolar lavage in the management of preschool children with severe asthma: pilot study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Associations of Snoring and Asthma Morbidity in the School Inner-City Asthma Study.The journal of allergy and clinical immunology. In practice · 2021Article
- [The relationship between adenoid and tonsil hypertrophy and asthma in children and analysis of changes in asthma after adenotonsillectomy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
- Association of adenotonsillectomy with asthma and upper respiratory infection: A nationwide cohort study.PloS one · 2020Article
- Tonsillectomy does not reduce asthma in children: A longitudinal follow-up study using a national sample cohort.Scientific reports · 2019Article
- Long-term effects of adenotonsillectomy on serum-specific immunoglobulin E.Pediatric research · 2017Article
- Multiparameter Single Cell Profiling of Airway Inflammatory Cells.Cytometry. Part B, Clinical cytometry · 2017Article
- Sleep-disordered breathing in children with asthma: a systematic review on the impact of treatment.Journal of asthma and allergy · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObservational studies suggest that asthma control improves after adenotonsillectomy, but longitudinal studies that correlate the effect of the procedure on the levels of biomarkers associated with airway inflammation are limited.
methodsWe conducted a longitudinal, observational study on pediatric patients, both with and without asthma, undergoing adenotonsillectomy. Asthma control test (ACT) scores and chitinase activity in the circulation were measured at time of surgery and at 6-mo follow-up.
resultsSixty-six children with asthma and 64 control subjects were enrolled. Mean ACT scores improved by three points (P < 0.001) after 6 mo. 85% of children with poorly controlled asthma demonstrated an increase in ACT score of at least three points or a decrease in emergency department/urgent care visits, oral corticosteroid courses, or rescue short acting bronchodilator usage. Chitinase activity decreased significantly in asthmatics who improved (P < 0.01). Higher chitinase activity levels at baseline were associated with improved asthma control following surgery (P < 0.01).
conclusionIn children with high preoperative circulating chitinase activity levels, asthma control and healthcare utilization were significantly improved after adenotonsillecotmy. Chitinase activity decreased after surgery in children with improved control. This suggests that adenotonsillectomy modulates chitinase activity, affecting airway inflammation and improving airway disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.