ArticleThe American journal of clinical nutrition2014
The marriage of nutrigenomics with the microbiome: the case of infant-associated bifidobacteria and milk.
Article in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Human milk oligosaccharides in premature infants: absorption, excretion, and influence on the intestinal microbiota.Pediatric research · 2015Trial
- Time to rethink prevention of neonatal group B streptococcal disease.Seminars in immunopathology · 2026Review
- Present and future of microbiome-targeting therapeutics.The Journal of clinical investigation · 2025Review
- Persistent reduction ofFrontiers in immunology · 2025Article
- Human Milk Oligosaccharides: Decoding Their Structural Variability, Health Benefits, and the Evolution of Infant Nutrition.Nutrients · 2024Review
- Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria.FEMS microbiology reviews · 2023Review
- Identification ofMicroorganisms · 2021Article
- The Mean of Milk: A Review of Human Milk Oligosaccharide Concentrations throughout Lactation.Nutrients · 2021Review
- Nutrition and Rheumatoid Arthritis in the 'Omics' Era.Nutrients · 2021Review
- Maternal and Breast Milk Influences on the Infant Gut Microbiome, Enteric Health and Growth Outcomes of Rhesus Monkeys.Journal of pediatric gastroenterology and nutrition · 2019Article
- Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls.Microbiome · 2017Article
- Impact of probiotics on necrotizing enterocolitis.Seminars in perinatology · 2017Review
- High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice.Nature · 2016Article
- Lactation and Intestinal Microbiota: How Early Diet Shapes the Infant Gut.Journal of mammary gland biology and neoplasia · 2015Review
- Kinetic characterization of a novel endo-β-N-acetylglucosaminidase on concentrated bovine colostrum whey to release bioactive glycans.Enzyme and microbial technology · 2015Article
- Microbiota at Multiple Body Sites during Pregnancy in a Rural Tanzanian Population and Effects of Moringa-Supplemented Probiotic Yogurt.Applied and environmental microbiology · 2015Article
- Milk bioactives may manipulate microbes to mediate parent-offspring conflict.Evolution, medicine, and public health · 2015Review
- Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut.Pediatric research · 2015Review
- Where next for microbiome research?PLoS biology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Broadly, nutrigenomics examines the association of exogenous nutrients and molecular responses to maintain homeostasis in an individual. Phenotypic expression profiling, often transcriptomics, has been applied to identify markers and metabolic consequences of suboptimal diet, lifestyle, or both. The decade after the Human Genome Project has been marked with advances in high-throughput analysis of biological polymers and metabolites, prompting a rapid increase in characterization of the profound nature by which our symbiotic microbiota influences human physiology. Although the technology is widely accessible to assess microbiome composition, genetic potential, and global function, nutrigenomics studies often exclude the microbial contribution to host responses to ingested nutritive molecules. Perhaps a hallmark of coevolution, milk provides a dramatic example of a diet that promotes a particular microbial community structure, because the lower infant gastrointestinal tract is often dominated by bifidobacteria that flourish on milk glycans. Systems-level approaches should continue to be applied to examine the microbial communities in the context of their host's dietary habits and metabolic status. In addition, studies of isolated microbiota species should be encouraged to inform clinical studies and interventions as well as community studies. Whereas nutrigenomics research is beginning to account for resident microbiota, the need remains to consistently consider our microscopic partners in the human holobiont.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.