ArticleScientific reports2014
BurrH: a new modular DNA binding protein for genome engineering.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Prevalence and diversity of TAL effector-like proteins in fungal endosymbioticMicrobial genomics · 2024Article
- Transcription activator-like effector protects bacterial endosymbionts from entrapment within fungal hyphae.Current biology : CB · 2023Article
- A TAL effector-like protein of an endofungal bacterium increases the stress tolerance and alters the transcriptome of the host.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- High Prevalence of Integrative and Conjugative Elements Encoding Transcription Activator-Like Effector Repeats inFrontiers in microbiology · 2019Article
- A Conserved Basal Transcription Factor Is Required for the Function of Diverse TAL Effectors in Multiple Plant Hosts.Frontiers in plant science · 2017Article
- Exploiting the sequence diversity of TALE-like repeats to vary the strength of dTALE-promoter interactions.Synthetic biology (Oxford, England) · 2017Article
- A TALE-inspired computational screen for proteins that contain approximate tandem repeats.PloS one · 2017Article
- Behind the lines-actions of bacterial type III effector proteins in plant cells.FEMS microbiology reviews · 2016Review
- A host basal transcription factor is a key component for infection of rice by TALE-carrying bacteria.eLife · 2016Article
- DNA-binding proteins from marine bacteria expand the known sequence diversity of TALE-like repeats.Nucleic acids research · 2015Article
- MorTAL Kombat: the story of defense against TAL effectors through loss-of-susceptibility.Frontiers in plant science · 2015Review
- Article
- QueTAL: a suite of tools to classify and compare TAL effectors functionally and phylogenetically.Frontiers in plant science · 2015Article
- Exploring the transcription activator-like effectors scaffold versatility to expand the toolbox of designer nucleases.BMC molecular biology · 2014Article
- BuD, a helix-loop-helix DNA-binding domain for genome modification.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Programmable DNA-binding proteins from Burkholderia provide a fresh perspective on the TALE-like repeat domain.Nucleic acids research · 2014Article
- Genome engineering: Drosophila melanogaster and beyond.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The last few years have seen the increasing development of new DNA targeting molecular tools and strategies for precise genome editing. However, opportunities subsist to either improve or expand the current toolbox and further broaden the scope of possible biotechnological applications. Here we report the discovery and the characterization of BurrH, a new modular DNA binding protein from Burkholderia rhizoxinica that is composed of highly polymorphic DNA targeting modules. We also engineered this scaffold to create a new class of designer nucleases that can be used to efficiently induce in vivo targeted mutagenesis and targeted gene insertion at a desired locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.