ArticleProceedings. Biological sciences2014
Honeybees (Apis mellifera) learn to discriminate the smell of organic compounds from their respective deuterated isotopomers.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Olfactory coding in honeybees.Cell and tissue research · 2021Review
- Exploring the mechanism of olfactory recognition in the initial stage by modeling the emission spectrum of electron transfer.PloS one · 2020Article
- Validity Examination of the Dissipative Quantum Model of Olfaction.Scientific reports · 2017Article
- Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The role of metals in mammalian olfaction of low molecular weight organosulfur compounds.Natural product reports · 2017Review
- Quantum effects in biology: golden rule in enzymes, olfaction, photosynthesis and magnetodetection.Proceedings. Mathematical, physical, and engineering sciences · 2017Review
- Differential Odour Coding of Isotopomers in the Honeybee Brain.Scientific reports · 2016Article
- Implausibility of the vibrational theory of olfaction.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Laying a controversial smell theory to rest.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The understanding of physiological and molecular processes underlying the sense of smell has made considerable progress during the past three decades, revealing the cascade of molecular steps that lead to the activation of olfactory receptor (OR) neurons. However, the mode of primary interaction of odorant molecules with the OR proteins within the sensory cells is still enigmatic. Two different concepts try to explain these interactions: the 'odotope hypothesis' suggests that OR proteins recognize structural aspects of the odorant molecule, whereas the 'vibration hypothesis' proposes that intra-molecular vibrations are the basis for the recognition of the odorant by the receptor protein. The vibration hypothesis predicts that OR proteins should be able to discriminate compounds containing deuterium from their common counterparts which contain hydrogen instead of deuterium. This study tests this prediction in honeybees (Apis mellifera) using the proboscis extension reflex learning in a differential conditioning paradigm. Rewarding one odour (e.g. a deuterated compound) with sucrose and not rewarding the respective analogue (e.g. hydrogen-based odorant) shows that honeybees readily learn to discriminate hydrogen-based odorants from their deuterated counterparts and supports the idea that intra-molecular vibrations may contribute to odour discrimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.