ArticleProceedings. Biological sciences2014
Population-level effects of suppressing fever.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Long-term health effects of antipyretic drug use in the aging population: a systematic review.Journal of medicine and life · 2024Pooled it
- Faster recovery and reduced paracetamol use - a meta-analysis of EPs 7630 in children with acute respiratory tract infections.BMC pediatrics · 2019Pooled it
- Febrile-range temperature selectively limits sustained pDC-Derived IFN-α via attenuation of STAT1-Dependent feedback signaling.Cell insight · 2026Article
- Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Radioactive contamination and climate warming affect physiological performance of Chornobyl barn swallows.PloS one · 2025Article
- The immunology of sickness metabolism.Cellular & molecular immunology · 2024Review
- NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress.Nature communications · 2024Article
- Fever-like temperature impacts on Staphylococcus aureus and Pseudomonas aeruginosa interaction, physiology, and virulence both in vitro and in vivo.BMC biology · 2024Article
- Prostaglandin ETemperature (Austin, Tex.) · 2024Review
- Article
- Neutrophil extracellular traps formation and clearance is enhanced in fever and attenuated in hypothermia.Frontiers in immunology · 2023Article
- LPS-Induced Inhibition of miR-143 Expression in Brown Adipocytes Promotes Thermogenesis and Fever.International journal of molecular sciences · 2022Article
- Comparison of the Effective Reproduction Number (Rt) Estimation Methods of COVID-19 Using Simulation Data Based on Available Data from Iran, USA, UK, India, and Brazil.Journal of research in health sciences · 2022Article
- How the epidemiology of disease-resistant and disease-tolerant varieties affects grower behaviour.Journal of the Royal Society, Interface · 2022Article
- Potential for Further Mismanagement of Fever During COVID-19 Pandemic: Possible Causes and Impacts.Frontiers in medicine · 2022Article
- Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses.PLoS biology · 2021Article
- Role of fever and ambient temperature in COVID-19.Expert review of respiratory medicine · 2021Article
- Effect of a fever in viral infections - the 'Goldilocks' phenomenon?World journal of clinical cases · 2021Review
- Live fast, die young and sleep later: Life history strategy and human sleep behavior.Evolution, medicine, and public health · 2021Article
- Let fever do its job: The meaning of fever in the pandemic era.Evolution, medicine, and public health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fever is commonly attenuated with antipyretic medication as a means to treat unpleasant symptoms of infectious diseases. We highlight a potentially important negative effect of fever suppression that becomes evident at the population level: reducing fever may increase transmission of associated infections. A higher transmission rate implies that a larger proportion of the population will be infected, so widespread antipyretic drug use is likely to lead to more illness and death than would be expected in a population that was not exposed to antipyretic pharmacotherapies. We assembled the published data available for estimating the magnitudes of these individual effects for seasonal influenza. While the data are incomplete and heterogeneous, they suggest that, overall, fever suppression increases the expected number of influenza cases and deaths in the US: for pandemic influenza with reproduction number , the estimated increase is 1% (95% CI: 0.0-2.7%), whereas for seasonal influenza with , the estimated increase is 5% (95% CI: 0.2-12.1%).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.