ReviewCurrent opinion in allergy and clinical immunology2014
The relationships between environmental bacterial exposure, airway bacterial colonization, and asthma.
Review in Current opinion in allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Does antimicrobial therapy improve outcomes in horses with severe equine asthma and a positive tracheal wash bacterial culture?Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2018Trial
- Associations Between Indoor Fungal Community Structures and Environmental Factors: Insights from the Evidence-Driven Indoor Air-Quality Improvement Study.Journal of fungi (Basel, Switzerland) · 2025Article
- MLFLHMDA: predicting human microbe-disease association based on multi-view latent feature learning.Frontiers in microbiology · 2024Article
- Temporal changes of the respiratory microbiota as cats transition from health to experimental acute and chronic allergic asthma.Frontiers in veterinary science · 2022Article
- The azithromycin to prevent wheezing following severe RSV bronchiolitis-II clinical trial: Rationale, study design, methods, and characteristics of study population.Contemporary clinical trials communications · 2021Article
- Modern urbanization has reshaped the bacterial microbiome profiles of house dust in domestic environments.The World Allergy Organization journal · 2020Article
- The Interactions of Airway Bacterial and Fungal Communities in Clinically Stable Asthma.Frontiers in microbiology · 2020Article
- A Novel Approach Based on Bipartite Network Recommendation and KATZ Model to Predict Potential Micro-Disease Associations.Frontiers in genetics · 2019Article
- Inactivation of Pure Bacterial Biofilms by Impaction of Aerosolized Consumer Products Containing Nanoparticulate Metals.Environmental science. Nano · 2018Article
- Early-life gut microbial colonization shapes Th1/Th2 balance in asthma model in BALB/c mice.BMC microbiology · 2017Article
- The interplay between host immune cells and gut microbiota in chronic inflammatory diseases.Experimental & molecular medicine · 2017Review
- IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma.Scientific reports · 2017Article
- Advanced Role of Neutrophils in Common Respiratory Diseases.Journal of immunology research · 2017Review
- Oral Probiotics Alter Healthy Feline Respiratory Microbiota.Frontiers in microbiology · 2017Article
- 'The Microbiome and the Pathophysiology of Asthma'.Respiratory research · 2016Review
- Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention.Current opinion in allergy and clinical immunology · 2016Review
- TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD.PloS one · 2016Article
- Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma?Mediators of inflammation · 2016Review
- Endotoxin Exposure: Predictors and Prevalence of Associated Asthma Outcomes in the United States.American journal of respiratory and critical care medicine · 2015Article
- Neutrophils in respiratory syncytial virus infection: A target for asthma prevention.The Journal of allergy and clinical immunology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewRecent application of advanced culture-independent molecular techniques for the identification of microorganisms has contributed to our knowledge on the role of early-life microbial exposure and colonization in health and disease. The purpose of this review is to present the current perspectives regarding the role of microbial exposure and airway bacterial colonization on the development and the activity of asthma. RECENT
findingsRecent findings continue to support the protective role of early-life diverse microbial exposure against the development of atopic diseases. However, airway bacterial colonization early in life serves as a risk factor for the development of asthma. Culture-independent molecular techniques for the identification of microorganisms have challenged the traditional paradigm that the lower airway is a sterile compartment. Asthmatics, compared with nonasthmatics, appear to have a different lung microbiome composition and some of these differences might contribute to asthma activity, severity, and corticosteroid response. SUMMARY: Bacterial presence in the airway appears to influence the inception and may affect the activity of asthma. Complex interactions between different types and routes of bacterial exposures, the airway, and the immune system early in life may determine whether these exposures augment or reduce the risk of asthma development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.