Trial reportCerebral cortex (New York, N.Y. : 1991)2015
Cerebral Lateralization is Protective in the Very Prematurely Born.
Trial report in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 62 citations in OpenAlex.
- Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants.Scientific reports · 2021Trial
- Neural compensation in adulthood following very preterm birth demonstrated during a visual paired associates learning task.NeuroImage. Clinical · 2014Trial
- Rightward brain structural asymmetry in young children with autism.Molecular psychiatry · 2025Article
- Early life brain network connectivity antecedents of executive function in children born preterm.Communications biology · 2025Article
- Lateralization of Neural Speech Discrimination at Birth Is a Predictor for Later Language Development.Developmental science · 2025Article
- Cerebral magnetic resonance spectroscopy - insights into preterm brain injury.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- A multi-level analysis of motor and behavioural dynamics in 9-month-old preterm and term-born infants during changing emotional and interactive contexts.Scientific reports · 2025Article
- Article
- Developmental trajectories of the default mode, frontoparietal, and salience networks from the third trimester through the newborn period.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Microstructural alterations in association tracts and language abilities in schoolchildren born very preterm and with poor fetal growth.Pediatric radiology · 2023Article
- Language lateralization in very preterm children: associating dichotic listening to interhemispheric connectivity and language performance.Pediatric research · 2022Article
- Atypical Intrinsic Hemispheric Interaction Associated with Autism Spectrum Disorder Is Present within the First Year of Life.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Structural and functional brain asymmetries in the early phases of life: a scoping review.Brain structure & function · 2022Article
- Extracallosal Structural Connectivity Is Positively Associated With Language Performance in Well-Performing Children Born Extremely Preterm.Frontiers in pediatrics · 2022Article
- Functional Hyperconnectivity during a Stories Listening Task in Magnetoencephalography Is Associated with Language Gains for Children Born Extremely Preterm.Brain sciences · 2021Article
- Distinct effects of prematurity on MRI metrics of brain functional connectivity, activity, and structure: Univariate and multivariate analyses.Human brain mapping · 2021Article
- Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approach.NeuroImage. Clinical · 2021Article
- Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach.medRxiv : the preprint server for health sciences · 2020Article
- Rewiring the extremely preterm brain: Altered structural connectivity relates to language function.NeuroImage. Clinical · 2020Article
- Data-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network.Schizophrenia bulletin · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Individuals born prematurely are at risk for developmental delay, and converging data suggest alterations in neural networks in the developing preterm brain. Nevertheless, those critical period processes such as cerebral lateralization that underlie these findings remain largely unexplored. To test the hypothesis that preterm birth alters the fundamental program of corticogenesis in the developing brain, we interrogated cerebral lateralization at rest in very prematurely born participants and term controls at young adulthood. Employing a novel, voxel-based measure of functional connectivity, these data demonstrate for the first time that cerebral lateralization of functional connectivity in right hemisphere language homologs is altered for very preterm participants. Very preterm participants with no evidence for severe brain injury exhibited a significant decrease in right hemisphere lateralization in the right parietal and temporal lobes in this data driven analysis. Further, for the very preterm participants, but not the term participants, these fundamental alterations in the cerebral lateralization for language significantly correlate with language scores. These findings provide evidence that cerebral asymmetry is both plastic and experiential, and suggest the need for further study of underlying environmental factors responsible for these changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.