ArticleThe Journal of biological chemistry2014
Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Polyphenols alleviate metabolic disorders: the role of ubiquitin-proteasome system.Frontiers in nutrition · 2024Review
- New insight of obesity-associated NAFLD: Dysregulated "crosstalk" between multi-organ and the liver?Genes & diseases · 2023Review
- Myostatin serum levels in children with type 1 diabetes mellitus.Hormones (Athens, Greece) · 2021Article
- Insulin action at a molecular level - 100 years of progress.Molecular metabolism · 2021Review
- Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of PhosphofructokinaseFrontiers in cell and developmental biology · 2021Article
- Unraveling the molecular heterogeneity in type 2 diabetes: a potential subtype discovery followed by metabolic modeling.BMC medical genomics · 2020Article
- Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps.Nutrients · 2020Review
- Major determinants of circulating myostatin in polycystic ovary syndrome.Experimental and therapeutic medicine · 2019Article
- Multi-omic analysis of signalling factors in inflammatory comorbidities.BMC bioinformatics · 2018Article
- Myostatin inhibits glucose uptake via suppression of insulin-dependent and -independent signaling pathways in myoblasts.Physiological reports · 2018Article
- Chronic Kidney Disease-Induced Insulin Resistance: Current State of the Field.Current diabetes reports · 2018Review
- Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs.Oncotarget · 2017Article
- Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population.Scientific reports · 2016Article
- AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.Cell · 2016Article
- Skeletal muscle as a therapeutic target for delaying type 1 diabetic complications.World journal of diabetes · 2015Review
- SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise.The Journal of biological chemistry · 2015Article
- Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.The Journal of physiology · 2015Article
- Does myostatin induce insulin resistance?The Journal of biological chemistry · 2014Article
Corrections and comments
- Retraction · 2016-07-01Falsification/Fabrication of Image · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author ·
- Commented on by
- Retracted
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date a plethora of evidence has clearly demonstrated that continued high calorie intake leads to insulin resistance and type-2 diabetes with or without obesity. However, the necessary signals that initiate insulin resistance during high calorie intake remain largely unknown. Our results here show that in response to a regimen of high fat or high glucose diets, Mstn levels were induced in muscle and liver of mice. High glucose- or fat-mediated induction of Mstn was controlled at the level of transcription, as highly conserved carbohydrate response and sterol-responsive (E-box) elements were present in the Mstn promoter and were revealed to be critical for ChREBP (carbohydrate-responsive element-binding protein) or SREBP1c (sterol regulatory element-binding protein 1c) regulation of Mstn expression. Further molecular analysis suggested that the increased Mstn levels (due to high glucose or fatty acid loading) resulted in increased expression of Cblb in a Smad3-dependent manner. Casitas B-lineage lymphoma b (Cblb) is an ubiquitin E3 ligase that has been shown to specifically degrade insulin receptor substrate 1 (IRS1) protein. Consistent with this, our results revealed that elevated Mstn levels specifically up-regulated Cblb, resulting in enhanced ubiquitin proteasome-mediated degradation of IRS1. In addition, over expression or knock down of Cblb had a major impact on IRS1 and pAkt levels in the presence or absence of insulin. Collectively, these observations strongly suggest that increased glucose levels and high fat diet, both, result in increased circulatory Mstn levels. The increased Mstn in turn is a potent inducer of insulin resistance by degrading IRS1 protein via the E3 ligase, Cblb, in a Smad3-dependent manner.
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