ArticleMolecules (Basel, Switzerland)2014
Synthesis of 4-methoxybenzoylhydrazones and evaluation of their antiglycation activity.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 36 citations in OpenAlex.
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- Synthesis of promising brominated flavonoids as antidiabetic and anti-glycation agents.Scientific reports · 2025Article
- Synthesis of Fluorinated Hydrazinylthiazole Derivatives: A Virtual and Experimental Approach to Diabetes Management.ACS omega · 2023Article
- Synthetic Transformation of 2-{2-Fluoro[1,1'-biphenyl]-4-yl} Propanoic Acid into Hydrazide-Hydrazone Derivatives:ACS omega · 2022Article
- Bio-Oriented Synthesis of Novel (S)-Flurbiprofen Clubbed Hydrazone Schiff's Bases for Diabetic Management: In Vitro and In Silico Studies.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives.Turkish journal of chemistry · 2020Article
- Design, Synthesis, Photophysical Properties, Biological Estimation and Molecular Docking Studies of Novel Schiff Base Derivatives as Potential Urease Inhibitors.Journal of fluorescence · 2018Article
- Article
- Prevention of non-enzymatic glycosylation (glycation): Implication in the treatment of diabetic complication.International journal of health sciences · 2016Review
- Crystal structure of (E)-N'-benzyl-idene-2-meth-oxy-benzohydrazide.Acta crystallographica. Section E, Structure reports online · 2014Article
- Synthesis of novel bisindolylmethane Schiff bases and their antibacterial activity.Molecules (Basel, Switzerland) · 2014Article
- Phenoxyacetohydrazide Schiff bases: β-glucuronidase inhibitors.Molecules (Basel, Switzerland) · 2014Article
- Synthesis, crystal structure, DFT studies and evaluation of the antioxidant activity of 3,4-dimethoxybenzenamine schiff bases.Molecules (Basel, Switzerland) · 2014Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of 4-methoxybenzoylhydrazones 1-30 was synthesized and the structures of the synthetic derivatives elucidated by spectroscopic methods. The compounds showed a varying degree of antiglycation activity, with IC50 values ranging between 216.52 and 748.71 µM, when compared to a rutin standard (IC50=294.46±1.50 µM). Compounds 1 (IC50=216.52±4.2 µM), 3 (IC50=289.58±2.64 µM), 6 (IC50=227.75±0.53 µM), 7 (IC50=242.53±6.1) and 11 (IC50=287.79±1.59) all showed more activity that the standard, and these compounds have the potential to serve as possible leads for drugs to inhibit protein glycation in diabetic patients. A preliminary SAR study was performed.
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