Evidence map›Paper›PMID 24451220›Full record

ArticleInflammatory bowel diseases2014

Menstrual cycle changes in women with inflammatory bowel disease: a study from the ocean state Crohn's and colitis area registry.

Sumona Saha, Ying-Qi Zhao, Samir A Shah, Silvia Degli Esposti, Sheldon Lidofsky, Sana Salih, Renee Bright, Meaghan Law, Heather Moniz, Nicole Flowers and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Inflammatory bowel diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  6. Article
  7. Influence of biological sex in inflammatory bowel diseases.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
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  16. Modulatory Effects of Pregnancy on Inflammatory Bowel Disease.Clinical and translational gastroenterology · 2019
    Review
  17. Updates on Women's Health Issues in Patients with Inflammatory Bowel Disease.Current treatment options in gastroenterology · 2018
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Sumona Saha*Division of Gastroenterology and Hepatology, and †Department of Biostatics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; ‡Division of Gastroenterology, Warren Alpert School of Medicine, Brown University, Providence, Rhode Island; §Division of Reproductive Endocrinology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; ‖Department of Pediatric Gastroenterology, Rhode Island Hospital, Providence, Rhode Island; ¶Division of Community Health, Centers for Disease Control and Prevention, Atlanta, Georgia; **Crohn's and Colitis Foundation of America, New York, New York; and ††Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine, Mount Sinai, New York, New York.
Ying-Qi Zhao
Samir A Shah
Silvia Degli Esposti
Sheldon Lidofsky
Sana Salih
Renee Bright
Meaghan Law
Heather Moniz
Nicole Flowers
Marjorie Merrick
Bruce E Sands
University of Wisconsin–Madison · USRhode Island Hospital · USBrown University · USCenters for Disease Control and Prevention · USCrohn's and Colitis Foundation · USIcahn School of Medicine at Mount Sinai · US

Funding

BUILDING INTERDISCIPLINARY RESEARCH CAREER IN WOMEN'S HEALTH (BIRCWH) SCHOLARSK12HD055894 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BURNSIDE, ELIZABETH S · 2007 to 2016
$4.1M
Practice Variation in Management of Inflammatory Bowel DiseaseU01DP000340 · DP · CROHN'S AND COLITIS FDN OF AMERICA, INC. · PI MERRICK, MARJORIE · 2005 to 2009
$2.1M
OSCCAR: A Novel, Population-based Prospective Inception Cohort of Inflammatory BoR21DK078555 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SANDS, BRUCE E · 2007 to 2008
$448k
NCCDPHP CDC HHS 1 UO1 DP000340-03NCCDPHP CDC HHS U01 DP000340NICHD NIH HHS K12 HD055894NICHD NIH HHS K12HD055894NIDDK NIH HHS 1R21DK078555-01NIDDK NIH HHS R21 DK078555
6 · The paper itself

Abstract

backgroundThe effect of the inflammatory bowel diseases (IBD) on menstrual function is largely unknown. The aims of this study were to determine whether changes in menstrual function occur in the year before IBD diagnosis or in the initial years after diagnosis.

methodsWomen aged 18 years and older in the Ocean State Crohn's and Colitis Area Registry with at least 2 years of follow-up were eligible for this study. All patients were enrolled within 6 months of IBD diagnosis and followed prospectively. Menstrual cycle characteristics were retrospectively assessed. To assess for changes over time, general linear models for correlated data were used for continuous outcomes, and generalized estimating equations were used for discrete outcomes.

resultsOne hundred twenty-one patients were studied. Twenty-five percent of patients experienced a change in cycle interval in the year before IBD diagnosis and 21% experienced a change in the duration of flow. Among women with dysmenorrhea, 40% experienced a change in the intensity of their menstrual pain and 31% experienced a change in its duration. Overall cycle regularity increased over time. Quality of life was significantly lower in women without regular cycles across all time points.

conclusionsChanges in menstrual function occur frequently in the year before IBD diagnosis; therefore, screening for menstrual irregularities should be considered in women with newly diagnosed IBD. Patients can be reassured that cycles typically become more regular over time.

Indexed as

AdultColitis, UlcerativeCrohn DiseaseFemaleFollow-Up StudiesHumansMenstrual CycleOceans and SeasPrognosisProspective StudiesRegistries

Identifiers

PMID24451220
PMCPMC4347838
OpenAlexW2003876325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.