ArticleInternational journal of molecular sciences2014
Temperature-responsive poly(ε-caprolactone) cell culture platform with dynamically tunable nano-roughness and elasticity for control of myoblast morphology.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Engineering multifunctional surface topography to regulate multiple biological responses.Biomaterials · 2025Review
- Improving Stability and Mechanical Strength of Electrospun Chitosan-Polycaprolactone Scaffolds Using Genipin Cross-linking for Biomedical Applications.Macromolecular rapid communications · 2025Article
- Smart biomaterial platforms: Controlling and being controlled by cells.Biomaterials · 2022Review
- Development of a new poly-ε-caprolactone with low melting point for creating a thermoset mask used in radiation therapy.Scientific reports · 2021Article
- Passive myocardial mechanical properties: meaning, measurement, models.Biophysical reviews · 2021Review
- Physical and dosimetric characterization of thermoset shape memory bolus developed for radiotherapy.Medical physics · 2020Article
- Next-Generation Biomaterials for Culture and Manipulation of Stem Cells.Cold Spring Harbor perspectives in biology · 2020Article
- Fluidity of Poly (ε-Caprolactone)-Based Material Induces Epithelial-to-Mesenchymal Transition.International journal of molecular sciences · 2020Article
- Smart hydrogels with high tunability of stiffness as a biomimetic cell carrier.Cell biology international · 2019Review
- Dynamically Tunable Cell Culture Platforms for Tissue Engineering and Mechanobiology.Progress in polymer science · 2017Article
- Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5.Theranostics · 2017Article
- Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances.ACS applied materials & interfaces · 2016Review
- Article
- Living biointerfaces based on non-pathogenic bacteria support stem cell differentiation.Scientific reports · 2016Article
- Inactivated Sendai Virus (HVJ-E) Immobilized Electrospun Nanofiber for Cancer Therapy.Materials (Basel, Switzerland) · 2015Article
- Shape-memory surfaces for cell mechanobiology.Science and technology of advanced materials · 2015Review
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Authors and funding
3 authors.
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Abstract
We developed a dynamic cell culture platform with dynamically tunable nano-roughness and elasticity. Temperature-responsive poly(ε-caprolactone) (PCL) films were successfully prepared by crosslinking linear and tetra-branched PCL macromonomers. By optimizing the mixing ratios, the crystal-amorphous transition temperature (Tm) of the crosslinked film was adjusted to the biological relevant temperature (~33 °C). While the crosslinked films are relatively stiff (50 MPa) below the Tm, they suddenly become soft (1 MPa) above the Tm. Correspondingly, roughness of the surface was decreased from 63.4-12.4 nm. It is noted that the surface wettability was independent of temperature. To investigate the role of dynamic surface roughness and elasticity on cell adhesion, cells were seeded on PCL films at 32 °C. Interestingly, spread myoblasts on the film became rounded when temperature was suddenly increased to 37 °C, while significant changes in cell morphology were not observed for fibroblasts. These results indicate that cells can sense dynamic changes in the surrounding environment but the sensitivity depends on cell types.
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