ArticleJournal of the American Chemical Society2014
Kinetic trapping of metastable amino acid polymorphs.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 35 citations in OpenAlex.
- Preparation and recrystallization of amorphous l-glutamic acid.RSC advances · 2026Article
- Computational structural, electronic and optical properties of the palmitic acid in its C form.Journal of molecular modeling · 2021Article
- Imaging of dehydration in particulate matter using Raman line-focus microscopy.Scientific reports · 2019Article
- Synchronous-digitization for Video Rate Polarization Modulated Beam Scanning Second Harmonic Generation Microscopy.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- Polarization-modulated second harmonic generation ellipsometric microscopy at video rate.Analytical chemistry · 2014Article
- Exciton coupling model for the emergence of second harmonic generation from assemblies of centrosymmetric molecules.The journal of physical chemistry. A · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Second harmonic generation (SHG) microscopy measurements indicate that inkjet-printed racemic solutions of amino acids can produce nanocrystals trapped in metastable polymorph forms upon rapid solvent evaporation. Polymorphism impacts the composition, distribution, and physico-kinetic properties of organic solids, with energetic arguments favoring the most stable polymorph. In this study, unfavored noncentrosymmetric crystal forms were observed by SHG microscopy. Polarization-dependent SHG measurement and synchrotron X-ray microdiffraction analysis of individual printed drops are consistent with formation of homochiral crystal production. Fundamentally, these results provide evidence supporting the ubiquity of Ostwald's Rule of Stages, describing the hypothesized transitioning of crystals between metastable polymorphic forms in the early stages of crystal formation. Practically, the presence of homochiral metastable forms has implications on chiral resolution and on solid form preparations relying on rapid solvent evaporation.
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Registered trials
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