ArticleBMC infectious diseases2014
The epidemiological impact of childhood influenza vaccination using live-attenuated influenza vaccine (LAIV) in Germany: predictions of a simulation study.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Live Attenuated Influenza Vaccine (LAIV) for Children for the Prevention of Influenza Illness in Sweden: A Cost-Effectiveness Analysis.Infectious diseases and therapy · 2026Article
- Vaccinating the German Population Aged 60 Years and Over with a Quadrivalent High-Dose Inactivated Influenza Vaccine Compared to Standard-Dose Vaccines: A Transmission and Budget Impact Model.PharmacoEconomics · 2023Article
- Cost-utility analysis of increasing uptake of universal seasonal quadrivalent influenza vaccine (QIV) in children aged 6 months and older in Germany.Human vaccines & immunotherapeutics · 2022Article
- Uptake and impact of vaccinating primary school children against influenza: Experiences in the fourth season of the live attenuated influenza vaccination programme, England, 2016/2017.Influenza and other respiratory viruses · 2022Article
- A model of influenza infection and vaccination in children aged under 5 years in Beijing, China.Human vaccines & immunotherapeutics · 2020Article
- Assessing direct and indirect effects of pediatric influenza vaccination in Germany by individual-based simulations.Human vaccines & immunotherapeutics · 2020Article
- Vaccinating children against influenza: overall cost-effective with potential for undesirable outcomes.BMC medicine · 2020Article
- Article
- The 2016 Lifetime Immunization Schedule, approved by the Italian scientific societies: A new paradigm to promote vaccination at all ages.Human vaccines & immunotherapeutics · 2017Article
- Variation in loss of immunity shapes influenza epidemics and the impact of vaccination.BMC infectious diseases · 2017Article
- Direct and indirect effects of influenza vaccination.BMC infectious diseases · 2017Article
- Is the impact of childhood influenza vaccination less than expected: a transmission modelling study.BMC infectious diseases · 2017Article
- Estimates of the Public Health Impact of a Pediatric Vaccination Program Using an Intranasal Tetravalent Live-Attenuated Influenza Vaccine in Belgium.Paediatric drugs · 2016Article
- Burden of influenza in Germany: a retrospective claims database analysis for the influenza season 2012/2013.The European journal of health economics : HEPAC : health economics in prevention and care · 2016Article
- Cost Effectiveness of Influenza Vaccine Choices in Children Aged 2-8 Years in the U.S.American journal of preventive medicine · 2016Article
- Cost-effectiveness analysis of the direct and indirect impact of intranasal live attenuated influenza vaccination strategies in children: alternative country profiles.Journal of market access & health policy · 2016Article
- Public health impact and cost-effectiveness of intranasal live attenuated influenza vaccination of children in Germany.The European journal of health economics : HEPAC : health economics in prevention and care · 2015Article
- Modeling infectious disease dynamics in the complex landscape of global health.Science (New York, N.Y.) · 2015Review
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Authors and funding
12 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoutine annual influenza vaccination is primarily recommended for all persons aged 60 and above and for people with underlying chronic conditions in Germany. Other countries have already adopted additional childhood influenza immunisation programmes. The objective of this study is to determine the potential epidemiological impact of implementing paediatric influenza vaccination using intranasally administered live-attenuated influenza vaccine (LAIV) in Germany.
methodsA deterministic age-structured model is used to simulate the population-level impact of different vaccination strategies on the transmission dynamics of seasonal influenza in Germany. In our base-case analysis, we estimate the effects of adding a LAIV-based immunisation programme targeting children 2 to 17 years of age to the existing influenza vaccination policy. The data used in the model is based on published evidence complemented by expert opinion.
resultsIn our model, additional vaccination of children 2 to 17 years of age with LAIV leads to the prevention of 23.9 million influenza infections and nearly 16 million symptomatic influenza cases within 10 years. This reduction in burden of disease is not restricted to children. About one third of all adult cases can indirectly be prevented by LAIV immunisation of children.
conclusionsOur results demonstrate that vaccinating children 2-17 years of age is likely associated with a significant reduction in the burden of paediatric influenza. Furthermore, annual routine childhood vaccination against seasonal influenza is expected to decrease the incidence of influenza among adults and older people due to indirect effects of herd protection. In summary, our model provides data supporting the introduction of a paediatric influenza immunisation programme in Germany.
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