ReviewBrain pathology (Zurich, Switzerland)2014
Schwannomas and their pathogenesis.
Review in Brain pathology (Zurich, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed, 2 syntheses or guidelines pooled it, 292 citations in OpenAlex.
- An overview on manifestation and management of glossopharyngeal schwannoma: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- Tumor Microenvironment in Sporadic Vestibular Schwannoma: A Systematic, Narrative Review.International journal of molecular sciences · 2023Pooled it
- Baseline characteristics of adults with neurofibromatosis enrolled on a psychosocial randomized controlled trial.Journal of neuro-oncology · 2022Trial
- Incidental discovery of a penile schwannoma during varicocelectomy: A rare case report.Urology case reports · 2026Article
- Article
- A case of intrapulmonary schwannoma in a patient with rectal carcinoma: A case report and literature review.Radiology case reports · 2026Article
- Incidental detection of adrenal schwannoma: a case report.Journal of medical case reports · 2026Article
- A Rare Case of Buccal Mucosa Schwannoma with Atypical Presentation.Annals of African medicine · 2026Article
- A Rare Case of Abdominal Wall Schwannoma.Cureus · 2026Article
- Ex Vivo Characterization Studies Identify Candidate Therapies for the Individualized Care ofCancers · 2026Article
- A Rare Case of Diffuse Extra-Cranial Schwannomatosis of the Trunk and Limbs.Clinical case reports · 2026Article
- Endobronchial Schwannoma Presenting as Persistent Cough: Diagnosis and Successful Bronchoscopic Resection.Cureus · 2026Article
- AI-driven label-free Raman spectromics for intraoperative spinal tumor assessment.NPJ digital medicine · 2026Article
- Article
- Schwannomatosis tumor modeling: progress and prospects for translational research.Journal of biological engineering · 2026Review
- Article
- Dual schwannomas of the ulnar nerve: the importance of surgical exploration beyond imaging: a case report.Journal of surgical case reports · 2026Article
- Endoscopic-assisted low-temperature plasma resection of tongue root schwannoma via oral approach: a case report and literature review.Frontiers in pediatrics · 2026Article
- Multiple Extensive Brachial Plexus Schwannomas.Cureus · 2026Article
- Case report: concurrent sigmoidectomy and schwannoma resection in a patient with recurrent diverticulitis.Journal of surgical case reports · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schwannomas may occur spontaneously, or in the context of a familial tumor syndrome such as neurofibromatosis type 2 (NF2), schwannomatosis and Carney's complex. Schwannomas have a variety of morphological appearances, but they behave as World Health Organization (WHO) grade I tumors, and only very rarely undergo malignant transformation. Central to the pathogenesis of these tumors is loss of function of merlin, either by direct genetic change involving the NF2 gene on chromosome 22 or secondarily to merlin inactivation. The genetic pathways and morphological features of schwannomas associated with different genetic syndromes will be discussed. Merlin has multiple functions, including within the nucleus and at the cell membrane, and this review summarizes our current understanding of the mechanisms by which merlin loss is involved in schwannoma pathogenesis, highlighting potential areas for therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.