ArticleAddiction (Abingdon, England)2014
Polygenic risk scores for smoking: predictors for alcohol and cannabis use?
Article in Addiction (Abingdon, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.The American journal of psychiatry · 2019Pooled it
- Predicting Genetic Risk for Impulsivity and Substance Use in Adolescence.medRxiv : the preprint server for health sciences · 2025Article
- The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population.Schizophrenia bulletin open · 2025Article
- Associations between polygenic risk scores and accelerated brain ageing in smokers.Psychological medicine · 2023Article
- Associations of polygenic risk scores for smoking heaviness and lifetime cannabis use with tobacco and cannabis co-use trajectories among African Americans.Drug and alcohol dependence · 2023Article
- Risk for alcohol use problems in severe mental illness: Interactions with sex and racial/ethnic minority status.Journal of affective disorders · 2023Article
- Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases.Medicine and science in sports and exercise · 2022Article
- Multi-Polygenic Analysis of Nicotine Dependence in Individuals of European Ancestry.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Article
- Genetics of substance use disorders in the era of big data.Nature reviews. Genetics · 2021Review
- Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort.Molecular brain · 2021Article
- Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology.Journal of abnormal psychology · 2020Review
- Genomic prediction of alcohol-related morbidity and mortality.Translational psychiatry · 2020Article
- Genome-Wide Association Study of Opioid Cessation.Journal of clinical medicine · 2020Article
- Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance.Translational psychiatry · 2019Article
- Genetics of alcohol use disorder: a review.Current opinion in psychology · 2019Review
- Association between polygenic risk for tobacco or alcohol consumption and liability to licit and illicit substance use in young Australian adults.Drug and alcohol dependence · 2019Article
- Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry.Addiction biology · 2019Article
- Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts.International journal of epidemiology · 2018Observational
- The genetic epidemiology of substance use disorder: A review.Drug and alcohol dependence · 2017Review
- Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).Molecular psychiatry · 2017Article
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7 authors.
Funding
Abstract
BACKGROUND AND
aimsA strong correlation exists between smoking and the use of alcohol and cannabis. This paper uses polygenic risk scores to explore the possibility of overlapping genetic factors. Those scores reflect a combined effect of selected risk alleles for smoking.
methodsSummary-level P-values were available for smoking initiation, age at onset of smoking, cigarettes per day and smoking cessation from the Tobacco and Genetics Consortium (n between 22,000 and 70,000 subjects). Using different P-value thresholds (0.1, 0.2 and 0.5) from the meta-analysis, sets of 'risk alleles' were defined and used to generate a polygenic risk score (weighted sum of the alleles) for each subject in an independent target sample from the Netherlands Twin Register (n = 1583). The association between polygenic smoking scores and alcohol/cannabis use was investigated with regression analysis.
resultsThe polygenic scores for 'cigarettes per day' were associated significantly with the number of glasses alcohol per week (P = 0.005, R2 = 0.4-0.5%) and cannabis initiation (P = 0.004, R2 = 0.6-0.9%). The polygenic scores for 'age at onset of smoking' were associated significantly with 'age at regular drinking' (P = 0.001, R2 = 1.1-1.5%), while the scores for 'smoking initiation' and 'smoking cessation' did not significantly predict alcohol or cannabis use.
conclusionsSmoking, alcohol and cannabis use are influenced by aggregated genetic risk factors shared between these substances. The many common genetic variants each have a very small individual effect size.
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