ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2014
Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Rhinovirus-16 induced temporal interferon responses in nasal epithelium links with viral clearance and symptoms.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Rhinovirus as a driver of airway T cell dynamics in children with treatment-refractory recurrent wheeze.JCI insight · 2025Article
- Potential Therapeutic Value of the STING Inhibitors.Molecules (Basel, Switzerland) · 2023Review
- Rhinovirus Infections and Their Roles in Asthma: Etiology and Exacerbations.The journal of allergy and clinical immunology. In practice · 2022Review
- Regulation and Function of Interferon-Lambda (IFNλ) and Its Receptor in Asthma.Frontiers in immunology · 2021Review
- Human TThe Journal of allergy and clinical immunology · 2020Article
- Childhood asthma heterogeneity at the era of precision medicine: Modulating the immune response or the microbiota for the management of asthma attack.Biochemical pharmacology · 2020Review
- Viruses and non-allergen environmental triggers in asthma.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2019Review
- Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?Respiratory research · 2018Review
- Association of ORMDL3 with rhinovirus-induced endoplasmic reticulum stress and type I Interferon responses in human leucocytes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Clinical characteristics of eosinophilic asthma exacerbations.Respirology (Carlton, Vic.) · 2017Article
- Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70.Journal of innate immunity · 2017Article
- Respiratory viral infections and host responses; insights from genomics.Respiratory research · 2016Review
- Virus/Allergen Interaction in Asthma Exacerbation.Annals of the American Thoracic Society · 2015Review
- Severity of virus-induced asthma symptoms is inversely related to resolution IFN-λ expression.The Journal of allergy and clinical immunology · 2015Article
- Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon.Scientific reports · 2014Article
- Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe majority of asthma exacerbations are related to viral respiratory infections. Some, but not all, previous studies have reported that low interferon responses in patients with asthma increase the risk for virus-induced exacerbations.
objectiveWe sought to determine the relationship between lower airway inflammatory biomarkers, specifically interferon gene expression, and the severity or presence of an exacerbation in asthmatics experiencing a naturally occurring viral infection.
methodsSputum samples were analysed from subjects in an asthma exacerbation study who experienced a confirmed viral infection. Subjects were monitored for daily symptoms, medication use and peak expiratory flow rate until baseline. Sputum samples were assessed for cell counts and gene expression.
resultsInterferon gamma expression was significantly greater in patients with asthma exacerbations compared to non-exacerbating patients (P = 0.002). IFN-α1, IFN-β1 and IFN-γ mRNA levels correlated with the peak Asthma Index (r = 0.58, P < 0.001; r = 0.57, P = 0.001; and r = 0.51, P = 0.004, respectively). Additionally, IL-13, IL-10 and eosinophil major basic protein mRNA levels were greater in patients with asthma exacerbations compared to non-exacerbating patients (P = 0.03, P = 0.06 and P = 0.02, respectively), and IL-13 mRNA correlated with the peak Asthma Index (P = 0.006).
conclusionsOur findings indicate that asthma exacerbations are associated with increased rather than decreased expression of interferons early in the course of infection. These findings raise the possibility that excessive virus-induced interferon production during acute infections can contribute to airway inflammation and exacerbations of asthma.
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Registered trials
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