Evidence map›Paper›PMID 24450411›Full record

ArticlePediatric diabetes2014

Cardiovascular health in adolescents with type 1 diabetes: the SEARCH CVD study.

Amy C Alman, Jennifer W Talton, R Paul Wadwa, Elaine M Urbina, Lawrence M Dolan, Stephen R Daniels, Richard F Hamman, Ralph B D'Agostino, Santica M Marcovina, Elizabeth J Mayer-Davis and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Pediatric diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  19. Staying Young at Heart: Cardiovascular Disease Prevention in Adolescents and Young Adults.Current treatment options in cardiovascular medicine · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Amy C AlmanDepartment of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, 33612, USA.
Jennifer W Talton
R Paul Wadwa
Elaine M Urbina
Lawrence M Dolan
Stephen R Daniels
Richard F Hamman
Ralph B D'Agostino
Santica M Marcovina
Elizabeth J Mayer-Davis
Dana M Dabelea
University of Colorado Denver · USCincinnati Children's Hospital Medical Center · USWake Forest University · USUniversity of North Carolina at Chapel Hill · USUniversity of South Florida · USUniversity of Washington · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
Sub Clinical Cardiovascular Disease in Youth (SEARCH CVD)R01DK078542 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2009 to 2010
$1.5M
NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR001425NCCDPHP CDC HHS U18 DP006134NIDDK NIH HHS R01 DK078542NIDDK NIH HHS R01-DK-078542
6 · The paper itself

Abstract

objectiveIn their Strategic Impact Goal Statement, the American Heart Association focused on primordial prevention of cardiovascular risk factors by defining metrics for ideal cardiovascular health (ICH). The prevalence of ICH among youth with type 1 diabetes is unknown. Youth with type 1 diabetes face an increased risk of cardiovascular disease (CVD) as they age. The purpose of this report was to examine the prevalence of ICH in a population of youth with type 1 diabetes and to examine the association of ICH with measures of cardiovascular structure and function. RESEARCH DESIGN AND

methodsThis report is based on SEARCH CVD an ancillary study to the SEARCH for Diabetes in Youth. A total of 190 adolescents with type 1 diabetes had complete data on all of the ICH metrics at baseline and had measures of arterial stiffness [pulse wave velocity (PWV), brachial distensibility (BrachD), and augmentation index (AIx)] and carotid intima-media thickness completed at a follow-up visit [on average 5 yr after baseline (interquartile range 4-5)].

resultsNo subjects met the ICH criteria for all 7 metrics. Meeting an increasing number of ICH metrics was significantly associated with lower arterial stiffness [lower PWV of the trunk (β = -0.02 ±0.01; p = 0.004) and AIx (β = -2.2 ±0.66; p = 0.001), and increased BrachD (β = 0.14 ±0.07; p = 0.04)].

conclusionsIncreasing number of ICH metrics was significantly associated with decreased arterial stiffness, but prevalence of ICH in this population was low. Youth with type 1 diabetes could benefit from improvements in their cardiovascular health.

Indexed as

Adolescent BehaviorHealth PromotionPatient ComplianceAdolescentAmerican Heart AssociationCardiovascular DiseasesColoradoCombined Modality TherapyDiabetes Mellitus, Type 1Diabetic AngiopathiesDiabetic CardiomyopathiesFemaleHumansHyperglycemiaLongitudinal StudiesMaleadolescentcarotid intima-media thicknessdiabetes mellitus, type 1pulse wave analysis

Identifiers

PMID24450411
PMCPMC4107203
OpenAlexW1480041787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.