ArticleProceedings of the National Academy of Sciences of the United States of America2014
Functional changes of the reward system underlie blunted response to social gaze in cocaine users.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Patient-Tailored Evidence-Based Approach for Developing Early Neuropsychological Training Programs in Addiction Settings.Neuropsychology review · 2019Pooled it
- Quality-of-life improvements associated with reductions in cocaine-positive urine drug screens.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Trial
- Self-regulation of the dopaminergic reward circuit in cocaine users with mental imagery and neurofeedback.EBioMedicine · 2018Trial
- Role of the 5-HTThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Trial
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- Aberrant type 2 dopamine and mu-opioid receptor availability in autism spectrum disorder.European journal of nuclear medicine and molecular imaging · 2026Article
- Article
- Cocaine polydrug use and its impact on intentional harm recognition: a high-density EEG study.BMC psychology · 2025Article
- Dissociating social reward learning and behavior in alcohol use disorder.Translational psychiatry · 2025Article
- Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI.Molecular psychiatry · 2024Article
- Investigating the impact of psychedelic drugs on social cognition defects: A scoping review protocol.PloS one · 2024Article
- Article
- Hub-connected functional connectivity within social brain network weakens the association with real-life social network in schizophrenia patients.European archives of psychiatry and clinical neuroscience · 2022Article
- Negative symptoms in alcohol use disorder: A pilot study applying the two-factor model of negative symptoms to patients with alcohol use disorder.Frontiers in psychiatry · 2022Article
- Psychedelic-Assisted Therapy for Substance Use Disorders and Potential Mechanisms of Action.Current topics in behavioral neurosciences · 2022Article
- In- and Out-Group Effects on Social Perception and Empathy in Cocaine Use Disorder.Frontiers in psychiatry · 2022Article
- Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction.Molecular psychiatry · 2021Article
- Functional connectivity of dorsolateral prefrontal cortex predicts cocaine relapse: implications for neuromodulation treatment.Brain communications · 2021Article
- Social Incentives Anticipation and Consummation: Investigating Neural Activity in Women Using Methamphetamine.Frontiers in psychology · 2020Article
- Using second-person neuroscience to elucidate the mechanisms of social interaction.Nature reviews. Neuroscience · 2019Review
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Social interaction deficits in drug users likely impede treatment, increase the burden of the affected families, and consequently contribute to the high costs for society associated with addiction. Despite its significance, the neural basis of altered social interaction in drug users is currently unknown. Therefore, we investigated basal social gaze behavior in cocaine users by applying behavioral, psychophysiological, and functional brain-imaging methods. In study I, 80 regular cocaine users and 63 healthy controls completed an interactive paradigm in which the participants' gaze was recorded by an eye-tracking device that controlled the gaze of an anthropomorphic virtual character. Valence ratings of different eye-contact conditions revealed that cocaine users show diminished emotional engagement in social interaction, which was also supported by reduced pupil responses. Study II investigated the neural underpinnings of changes in social reward processing observed in study I. Sixteen cocaine users and 16 controls completed a similar interaction paradigm as used in study I while undergoing functional magnetic resonance imaging. In response to social interaction, cocaine users displayed decreased activation of the medial orbitofrontal cortex, a key region of reward processing. Moreover, blunted activation of the medial orbitofrontal cortex was significantly correlated with a decreased social network size, reflecting problems in real-life social behavior because of reduced social reward. In conclusion, basic social interaction deficits in cocaine users as observed here may arise from altered social reward processing. Consequently, these results point to the importance of reinstatement of social reward in the treatment of stimulant addiction.
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