ArticleInternational forum of allergy & rhinology2014
Conductive olfactory losses in chronic rhinosinusitis? A computational fluid dynamics study of 29 patients.
Article in International forum of allergy & rhinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Conductive Mechanisms of Olfactory Dysfunction in Chronic Rhinosinusitis: A Focus on Nasal Airflow Dynamics and Olfactory Mucus.Clinical reviews in allergy & immunology · 2026Review
- [Analysis of influencing factors on secondary olfactory dysfunction in different types of chronic sinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Mechanisms, diagnosis, and treatment of olfactory dysfunction in rhinosinusitis.European journal of medical research · 2025Review
- Olfactory dysfunction and the role of stem cells in the regeneration of olfactory neurons.Heliyon · 2024Review
- Structures and functions of the normal and injured human olfactory epithelium.Frontiers in neural circuits · 2024Review
- Article
- Computational Fluid Dynamic Modeling Reveals Nonlinear Airway Stress during Trachea Development.The Journal of pediatrics · 2021Article
- Computational modeling of nasal nitric oxide flux from the paranasal sinuses: Validation against human experiment.Computers in biology and medicine · 2021Article
- Regional deposition of the allergens and micro-aerosols in the healthy human nasal airways.Journal of aerosol science · 2021Article
- Review
- The Application of Computational Fluid Dynamics in the Evaluation of Laryngotracheal Pathology.The Annals of otology, rhinology, and laryngology · 2019Article
- Diseases of the nasal cavity.Handbook of clinical neurology · 2019Review
- High quality statistical shape modelling of the human nasal cavity and applications.Royal Society open science · 2018Article
- Nasal Structural and Aerodynamic Features That May Benefit Normal Olfactory Sensitivity.Chemical senses · 2018Article
- Olfactory loss in chronic rhinosinusitis is associated with neuronal activation of c-Jun N-terminal kinase.International forum of allergy & rhinology · 2018Article
- Computational modeling and validation of human nasal airflow under various breathing conditions.Journal of biomechanics · 2017Article
- Superior turbinate eosinophilia correlates with olfactory deficit in chronic rhinosinusitis patients.The Laryngoscope · 2017Article
- Ethmoidectomy combined with superior meatus enlargement increases olfactory airflow.Laryngoscope investigative otolaryngology · 2017Article
- Computational fluid dynamics evaluation of posterior septectomy as a viable treatment option for large septal perforations.International forum of allergy & rhinology · 2017Article
- Computational fluid dynamics as surgical planning tool: a pilot study on middle turbinate resection.Anatomical record (Hoboken, N.J. : 2007) · 2014Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBesides sensorineural factors, conductive impediments likely contribute to olfactory losses in chronic rhinosinusitis (CRS) patients, yet no conclusive evidence exists. We aimed to examine possible conductive factors using computational fluid dynamics (CFD) models.
methodsA total of 29 CRS patients were assessed via odorant detection thresholds (ODTs), rhinomanometry (nasal resistance [NR]), acoustic rhinometry (minimum-cross-sectional area [MCA]) and computed tomography (CT) staging. CFD simulations of nasal airflow and odorant absorption to olfactory region were carried out based on individual CTs. Biopsies of olfactory epithelium (OE) were collected, cryosectioned, stained, and scored for erosion.
resultsSignificant correlations to ODTs were found for 3 variables: odor absorption in the olfactory region (r = -0.60, p < 0.01), MCA (r = -0.40, p < 0.05), and CT staging (r = 0.42, p < 0.05). However, significant findings were limited to ODTs of the highly soluble l-carvone. Multiple regression analysis revealed that these variables combined, with the addition of NR, can account for 65% of the total variance in ODTs. CT staging correlated significantly with OE erosion (r = 0.77, p < 0.01) and can replace the latter in the regression with comparable outcomes. Partial correlations suggest the contributions of both conductive and sensorineural variables are more prominent if adjusted for the effects of the other. Olfactory loss and inflammatory factors have strong bilateral involvement, whereas conductive factors are independent between sides. As validation, CFD-simulated NRs significantly correlated with rhinomanometrically assessed NRs (r = 0.60, p < 0.01).
conclusionBoth conductive and sensorineural mechanisms can contribute to olfactory losses in CRS. CFD modeling provides critical guidance in understanding the role of conductive impediments in olfactory dysfunction in CRS.
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