Trial reportPostgraduate medical journal1987
The origin of proteinuria at high altitude.
Trial report in Postgraduate medical journal, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- The impact of high altitude (hypobaric hypoxia) on insulin resistance in humans.Journal of physiology and biochemistry · 2025Review
- Effect of therapeutic erythrocytapheresis on outcomes and renal benefit in patients with high-altitude polycythemia: a real-world study.Scientific reports · 2024Article
- Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.Cardiovascular diabetology · 2024Article
- Where do you live and what do you do? Two questions that might impact your kidney health.Frontiers in nephrology · 2022Review
- Effects of high altitude on renal physiology and kidney diseases.Frontiers in physiology · 2022Review
- Postexercise urinary alpha-1 acid glycoprotein is not dependent on hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Health risk of travel for chronic kidney disease patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Review
- Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria.BMJ open sport & exercise medicine · 2020Article
- Multimodal analysis of the effects of dexamethasone on high-altitude cerebral oedema: protocol for a pilot study.Trials · 2019Article
- Dietary supplementation with L-lysine affects body weight and blood hematological and biochemical parameters in rats.Molecular biology reports · 2019Article
- Antihyperglycemic agents as novel natriuretic therapies in diabetic kidney disease.American journal of physiology. Renal physiology · 2018Review
- Urinary Alpha-1-Acid Glycoprotein Is a Sensitive Marker of Glomerular Protein Leakage at Altitude.High altitude medicine & biology · 2018Article
- Medicine and mechanisms in altitude sickness. Recommendations.Sports medicine (Auckland, N.Z.) · 1995Review
- Microalbuminuria in chronic obstructive lung disease.BMJ (Clinical research ed.) · 1993Article
- Altitude, training and human performance.Sports medicine (Auckland, N.Z.) · 1988Review
- Acute mountain sickness.Postgraduate medical journal · 1987Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary protein excretion was measured before and after the intravenous infusion of lysine in 14 normal subjects after 4-6 days' acclimatization at 4846 m. Urinary albumin excretion before lysine was elevated in 11 subjects but alpha 1-microglobulin was detected in only four. After lysine a large increase in albumin excretion occurred in all subjects. Together with the absence of alpha 1-microglobulin before lysine this implies that increased glomerular capillary permeability is the major cause of proteinuria after acclimatization to high altitude. The estimated minimum glomerular fluid albumin concentration was increased two to three fold above the published values in normal controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.