ArticleJournal of experimental botany2014
The chloride channel family gene CLCd negatively regulates pathogen-associated molecular pattern (PAMP)-triggered immunity in Arabidopsis.
Article in Journal of experimental botany, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Research Progress on Chloride Channel- and Transporter- Related Gene Families in Plants.International journal of molecular sciences · 2026Review
- Time-Series Elemental Imaging Reveals CAX-Dependent Redistribution Patterns for Anoxia Recovery.Journal of experimental botany · 2025Article
- Genome-wide identification of key genes related to chloride ion (ClBMC genomics · 2025Article
- Genome-Wide Identification, Molecular Evolution, and Expression Divergence ofFood science & nutrition · 2025Article
- CLC gene family inFrontiers in plant science · 2025Article
- Protein Structural Modeling and Transport Thermodynamics Reveal That Plant Cation-Chloride Cotransporters Mediate Potassium-Chloride Symport.International journal of molecular sciences · 2024Article
- Dissecting the causal polymorphism of the Lr67res multipathogen resistance gene.Journal of experimental botany · 2024Article
- Chloride salt enhances plant resistance to biotic stresses.Frontiers in plant science · 2024Article
- The Role of Chloride Channels in Plant Responses to NaCl.International journal of molecular sciences · 2023Review
- Quantitative trait locus mapping of osmotic stress response in the fungal wheat pathogen Zymoseptoria tritici.G3 (Bethesda, Md.) · 2023Article
- Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.Nature communications · 2023Article
- Review
- Expression of the wheat multipathogen resistance hexose transporter Lr67res is associated with anion fluxes.Plant physiology · 2023Article
- Molecular Cloning and Characterization of SaCLCd, SaCLCf, and SaCLCg, Novel Proteins of the Chloride Channel Family (CLC) from the HalophytePlants (Basel, Switzerland) · 2022Article
- Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1).eLife · 2022Article
- Genome-wide identification and expression analysis of the CLC gene family in pomegranate (Punica granatum) reveals its roles in salt resistance.BMC plant biology · 2020Article
- Identification of MAMP-Responsive Plasma Membrane-Associated Proteins inPathogens (Basel, Switzerland) · 2020Article
- CATION-CHLORIDE CO-TRANSPORTER 1 (CCC1) Mediates Plant Resistance againstPlant physiology · 2020Article
- Chloride as a Beneficial Macronutrient in Higher Plants: New Roles and Regulation.International journal of molecular sciences · 2019Review
- Large-Scale Investigation of Soybean Gene Functions by Overexpressing a Full-Length Soybean cDNA Library inFrontiers in plant science · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chloride channel (CLC) family genes are ubiquitous from prokaryotes to eukaryotes and encode proteins with both channel and transporter activities. The Arabidopsis thaliana genome encodes seven CLC genes, and their products are found in a variety of cellular compartments and have various physiological functions. However, a role for AtCLCs in plant innate immunity has not previously been demonstrated. Here it is reported that AtCLCd is a negative regulator of pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI). T-DNA insertion mutants of AtCLCd exhibited enhanced responses to the elicitor, flg22. The PTI phenotypes of the clcd mutants were rescued by expression of AtCLCd. Overexpression of AtCLCd led to impaired flg22-induced responses. In line with a role for AtCLCd in PTI, the clcd mutants were more resistant to a virulent strain of the bacterial pathogen Pseudomonas syringae pv. tomato DC3000 when spray inoculated, while AtCLCd-overexpressing lines displayed increased susceptibility to this pathogen. Interestingly, flg22 treatment was found to repress the expression of AtCLCd. In addition, its expression was elevated in mutants of the flg22 pattern recognition receptor (PRR) FLS2 and the PRR regulatory proteins BAK1 and BKK1, and reduced in an FLS2-overexpressing line. These latter findings indicate that FLS2 complexes regulate the expression of AtCLCd, further supporting a role for AtCLCd in PTI.
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