Evidence map›Paper›PMID 24449238›Full record

ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2014

Liquid biopsies: genotyping circulating tumor DNA.

Luis A Diaz, Alberto Bardelli

4 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 1,218 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,218citing papers in PubMed, 6 pooled it
65.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03090815 unknown statusnot on this mapstarted 2016, after this paper: background citation

Circulating Tumor DNA (ctDNA) as a Prognostic Tool in Patients With Advanced Lung Adenocarcinoma

Typeobservational_patient_registrySponsorThe University of Hong KongRan2016 to 2017Enrolled100ConditionsAdenocarcinoma of Lung (Disorder)ArmsSequencing of ctDNA in plasma
NCT03956940 naterminatednot on this mapstarted 2019, after this paper: background citation

A Sorafenib-Regorafenib Sequence Treatment Monitoring Study Using Liquid Biopsy

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2019 to 2021Enrolled18ConditionsHepatocarcinomaArmsIntplex test
NCT04163159 unknown statusnot on this mapstarted 2019, after this paper: background citation

Genetic Markers of Circulating Tumor DNA for Monitoring Breast Cancer in Patients of the Hospital San Juan de Dios From 2018 to 2020.

TypeobservationalSponsorUniversidad de Costa RicaRan2019 to 2020Enrolled25ConditionsMetastatic Breast Cancer, Mutation, Point
NCT04511559 unknown statusnot on this mapstarted 2020, after this paper: background citation

Methylation Analysis of Circulating Tumor DNA in Early Diagnosis and Prognostic Stratification in Patients With Gastric Cancer

TypeobservationalSponsorShanghai Zhongshan HospitalRan2020 to 2025Enrolled540ConditionsStomach Neoplasms, Circulating Tumor DNAArmsCirculating Tumor DNA Methylation Sequencing, tissue DNA Methylation Sequencing
3 · Its place in the literature

Who cites it

1,218 citing papers in PubMed, 6 syntheses or guidelines pooled it, 2,169 citations in OpenAlex.

  1. Pooled it
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  7. Trial
  8. Review
  9. Liquid biopsy in modern medicine: advancing diagnostics from molecular insights to clinical practice.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  10. Beyond the Needle: Is Liquid Biopsy the Future of Veterinary Medicine?International journal of molecular sciences · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. From Tumour to Bloodstream: Advancing PD-L1 Testing With Liquid Biopsies in Non-Small Cell Lung Cancer.Cytopathology : official journal of the British Society for Clinical Cytology · 2026
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

1,158 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Luis A DiazLuis A. Diaz Jr, Swim Across America Laboratory and Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD; and Alberto Bardelli, Institute for Cancer Research and Treatment at Candiolo, University of Torino, Candiolo, and the Fondazione Italiana per la Ricerca sul Cancro Institute of Molecular Oncology, Milan, Italy.
Alberto Bardelli
Johns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

Genotyping tumor tissue in search of somatic genetic alterations for actionable information has become routine practice in clinical oncology. Although these sequence alterations are highly informative, sampling tumor tissue has significant inherent limitations; tumor tissue is a single snapshot in time, is subject to selection bias resulting from tumor heterogeneity, and can be difficult to obtain. Cell-free fragments of DNA are shed into the bloodstream by cells undergoing apoptosis or necrosis, and the load of circulating cell-free DNA (cfDNA) correlates with tumor staging and prognosis. Moreover, recent advances in the sensitivity and accuracy of DNA analysis have allowed for genotyping of cfDNA for somatic genomic alterations found in tumors. The ability to detect and quantify tumor mutations has proven effective in tracking tumor dynamics in real time as well as serving as a liquid biopsy that can be used for a variety of clinical and investigational applications not previously possible.

Indexed as

BiopsyDNA, NeoplasmGenotypeHumansNeoplasmsDNA, Neoplasm

Identifiers

PMID24449238
PMCPMC4820760
OpenAlexW2027735722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.