Evidence map›Paper›PMID 24449235›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2014

Randomized noninferiority trial of telephone versus in-person genetic counseling for hereditary breast and ovarian cancer.

Marc D Schwartz, Heiddis B Valdimarsdottir, Beth N Peshkin, Jeanne Mandelblatt, Rachel Nusbaum, An-Tsun Huang, Yaojen Chang, Kristi Graves, Claudine Isaacs, Marie Wood and 10 more

3 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 144 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03006913 nacompletednot on this mapstarted 2017, after this paper: background citation

Comparison of 3 Modes of Genetic Counseling in High-Risk Public Hospital

TypeinterventionalSponsorUniversity of California, San FranciscoRan2017 to 2019Enrolled1,273ConditionsGenetic CounselingArmsIn-person, By phone, By video
NCT03959267 nacompletednot on this mapstarted 2017, after this paper: background citation

Testing a Culturally Adapted Telephone Genetic Counseling Intervention to Enhance Genetic Risk Assessment in Underserved Latinas at Risk of Hereditary Breast and Ovarian Cancer

TypeinterventionalSponsorGeorgetown UniversityRan2017 to 2021Enrolled37ConditionsBreast Cancer, Hereditary Breast CancerArmsTelephone Genetic Counseling
NCT04738708 recruitingnot on this mapstarted 2021, after this paper: background citation

Telegenetics or In-Person Genetic Counselling: A Comparison of Clinical Outcomes and Cost

TypeobservationalSponsorNational Cancer Centre, SingaporeRan2021 to 2026Enrolled150ConditionsGenetic CounsellingArmsPatients referred to CGS at NCCS for HBOC or Lynch syndrome pre-test genetic counselling.
3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Systematic evidence review and meta-analysis of outcomes associated with cancer genetic counseling.Genetics in medicine : official journal of the American College of Medical Genetics · 2024
    Pooled it
  4. Decision coaching for people making healthcare decisions.The Cochrane database of systematic reviews · 2021
    Pooled it
  5. Virtual Care in Patients with Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2021
    Pooled it
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  18. The Genetic Education for Men (GEM) Trial: Development of Web-Based Education for Untested Men in BRCA1/2-Positive Families.Journal of cancer education : the official journal of the American Association for Cancer Education · 2021
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84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Marc D SchwartzMarc D. Schwartz, Beth N. Peshkin, Jeanne Mandelblatt, Rachel Nusum, An-Tsun Huang, Yaojen Chang, Kristi Graves, Claudine Isaacs, George Luta, Sarah Kelleher, Kara-Grace Leventhal, Patti Vegella, Angie Tong, and Lesley King, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC; Heiddis B. Valdimarsdottir, Mount Sinai School of Medicine, New York, NY; Marie Wood and Wendy McKinnon, Familial Cancer Program of the Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT; Judy Garber and Shelley McCormick, Dana-Farber Cancer Institute-Harvard Medical School, Boston, MA; and Anita Y. Kinney, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT.
Heiddis B Valdimarsdottir
Beth N Peshkin
Jeanne Mandelblatt
Rachel Nusbaum
An-Tsun Huang
Yaojen Chang
Kristi Graves
Claudine Isaacs
Marie Wood
Wendy McKinnon
Judy Garber
Shelley McCormick
Anita Y Kinney
George Luta
Sarah Kelleher
Kara-Grace Leventhal
Patti Vegella
Angie Tong
Lesley King

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
Comparative Modeling: Informing Breast Cancer Control Practice & PolicyU01CA152958 · NCI · GEORGETOWN UNIVERSITY · PI BERRY, DONALD A, DE KONING, HARRY J · 2010 to 2015
$7.6M
Telephone-Based Genetic Counseling: An Equivalence TrialR01CA108933 · NCI · GEORGETOWN UNIVERSITY · PI SCHWARTZ, MARC D · 2004 to 2008
$2.3M
NCI NIH HHS P30 CA051008NCI NIH HHS P30CA051008NCI NIH HHS R01 CA108933NCI NIH HHS R01CA108933NCI NIH HHS U01 CA152958
6 · The paper itself

Abstract

purposeAlthough guidelines recommend in-person counseling before BRCA1/BRCA2 gene testing, genetic counseling is increasingly offered by telephone. As genomic testing becomes more common, evaluating alternative delivery approaches becomes increasingly salient. We tested whether telephone delivery of BRCA1/2 genetic counseling was noninferior to in-person delivery. PATIENTS AND

methodsParticipants (women age 21 to 85 years who did not have newly diagnosed or metastatic cancer and lived within a study site catchment area) were randomly assigned to usual care (UC; n = 334) or telephone counseling (TC; n = 335). UC participants received in-person pre- and post-test counseling; TC participants completed all counseling by telephone. Primary outcomes were knowledge, satisfaction, decision conflict, distress, and quality of life; secondary outcomes were equivalence of BRCA1/2 test uptake and costs of delivering TC versus UC.

resultsTC was noninferior to UC on all primary outcomes. At 2 weeks after pretest counseling, knowledge (d = 0.03; lower bound of 97.5% CI, -0.61), perceived stress (d = -0.12; upper bound of 97.5% CI, 0.21), and satisfaction (d = -0.16; lower bound of 97.5% CI, -0.70) had group differences and confidence intervals that did not cross their 1-point noninferiority limits. Decision conflict (d = 1.1; upper bound of 97.5% CI, 3.3) and cancer distress (d = -1.6; upper bound of 97.5% CI, 0.27) did not cross their 4-point noninferiority limit. Results were comparable at 3 months. TC was not equivalent to UC on BRCA1/2 test uptake (UC, 90.1%; TC, 84.2%). TC yielded cost savings of $114 per patient.

conclusionGenetic counseling can be effectively and efficiently delivered via telephone to increase access and decrease costs.

Indexed as

Breast NeoplasmsDecision MakingGenetic TestingMutationOvarian NeoplasmsTelephoneAdultAgedAged, 80 and overConflict, PsychologicalCost-Benefit AnalysisFemaleGenes, BRCA1Genes, BRCA2Genetic CounselingHealth Knowledge, Attitudes, Practice

Identifiers

PMID24449235
PMCPMC3927731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.