ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2014
Ocular diseases in metastatic cutaneous melanoma: review of 108 consecutive patients in two German tertiary centers.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
- Spectrum of presentation of intraocular metastases from cutaneous melanoma in the era of immunotherapy and targeted therapies.Eye (London, England) · 2025Article
- Idiopathic Acute Exudative Polymorphous Vitelliform Maculopathy: A Case Report.International medical case reports journal · 2025Article
- Idiopathic acute exudative polymorphous vitelliform maculopathy: the importance of multimodal imaging, systemic workup and genetic testing.BMJ case reports · 2023Article
- Acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM) associated with choroidal melanoma.International journal of retina and vitreous · 2021Article
- Paraneoplastic acute exudative polymorphous vitelliform maculopathy improved with intravitreal methotrexate.American journal of ophthalmology case reports · 2020Article
- Acute Exudative Polymorphous Vitelliform Maculopathy Syndrome; natural history and evolution of fundal and OCT images over time.BMJ case reports · 2018Article
- Successful long-term treatment of paraneoplastic optic neuropathy with mycophenolate mofetil, prednisone, and plasmapheresis.American journal of ophthalmology case reports · 2017Article
- [Paraneoplastic serous retinopathies: hormones, mediators, and inhibitors].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2017Article
- [Vitreous metastasis of malignant cutaneous melanoma during treatment with ipilimumab].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2017Article
- Exudative Polymorphous Vitelliform Retinopathy: Importance of Early Recognition of the Condition in Patients with Metastatic Melanoma.Ophthalmology and therapy · 2016Article
- Clinical applications of fundus autofluorescence in retinal disease.International journal of retina and vitreous · 2016Review
- Article
- Fundus Autofluorescence and Clinical Applications.Journal of ophthalmic & vision researchReview
- Recurrence of Pancreatic Cancer Presenting as Choroidal Metastasis: A Case Report.Case reports in ophthalmologyArticle
- Two-Year Follow-Up of Idiopathic Acute Exudative Polymorphous Vitelliform Maculopathy: Case Report and Literature Review.Journal of current ophthalmologyArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the incidence and spectrum of ocular disease in patients with metastatic cutaneous melanoma.
methodsOne hundred and eight consecutive patients with metastatic cutaneous melanoma were screened for ocular diseases using standardized eye examination, including measurement of visual acuity and intraocular pressure, slit-lamp examination, funduscopy in mydriasis, and spectral-domain optical coherence tomography (SDOCT) of the retina. Selected cases with atypical findings underwent electrophysiological studies. One patient was examined for hypercortisolism by a dexamethasone suppression test.
resultsOcular diseases were found in 65 out of 108 patients (60 %) with metastatic cutaneous melanoma, significantly more often in older patients (p = 0.004). Cataract was present in 27 patients (25 %), pseudophakia in 22 patients (20 %), macular disease in 29 patients (28 %), diabetic retinopathy in ten patients (9 %), hypertensive retinal disease in 14 patients (13 %), retinal venous and arterial occlusive disease in three patients (3 %), optic neuropathy in four patients (4 %), and uveitis in one patient (1 %). Eight patients (8 %) had choroidal or iridal nevi, one patient (1 %) choroidal hemangioma, and one patient (1 %) choroidal metastasis. No patient had periocular neoplastic lesions. Paraneoplastic retinopathy manifesting as acute exudative polymorphous vitelliform maculopathy (AEPVM)-like disease was diagnosed in two patients (2 %) with multifocal central serous chorioretinopathy and development of vitelliform or fibrin-like subretinal deposits in one patient.
conclusionsPatients with metastatic cutaneous melanoma reveal ocular diseases with a spectrum similar to the normal population of this age range. Very rarely, uveal metastasis as well as paraneoplastic retinopathy can occur.
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