ArticlePsychopharmacology2014
The effects of age at the onset of drinking to intoxication and chronic ethanol self-administration in male rhesus macaques.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 36 citations in OpenAlex.
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- Long-term drinking stability in the open-access self-administration monkey model.Alcohol (Fayetteville, N.Y.) · 2023Article
- Influence of social rank on the development of long-term ethanol drinking trajectories in cynomolgus monkeys.Alcohol, clinical & experimental research · 2023Article
- Dose-response effects of alcohol on biochemical markers of bone turnover in non-human primates: Effects of species, sex and age of onset of drinking.Bone reports · 2022Article
- Pairing food and drink: A physiological model of blood ethanol levels for a variety of drinking behaviors.Mathematical biosciences · 2022Article
- Effects of adolescent alcohol exposure via oral gavage on adult alcohol drinking and co-use of alcohol and nicotine in Sprague Dawley rats.Drug and alcohol dependence · 2022Article
- Replicability in measures of attentional set-shifting task performance predicting chronic heavy drinking in rhesus monkeys.Alcohol (Fayetteville, N.Y.) · 2021Article
- Rich Club Characteristics of Alcohol-Naïve Functional Brain Networks Predict Future Drinking Phenotypes in Rhesus Macaques.Frontiers in behavioral neuroscience · 2021Article
- Nonhuman animal models of substance use disorders: Translational value and utility to basic science.Drug and alcohol dependence · 2020Review
- Voluntary Chronic Heavy Alcohol Consumption in Male Rhesus Macaques Suppresses Cancellous Bone Formation and Increases Bone Marrow Adiposity.Alcoholism, clinical and experimental research · 2019Article
- Discriminative Stimulus Effects and Metabolism of Ethanol in Rhesus Monkeys.Alcoholism, clinical and experimental research · 2019Article
- Time for a Drink? A Mathematical Model of Non-human Primate Alcohol Consumption.Frontiers in applied mathematics and statistics · 2019Article
- Low cognitive flexibility as a risk for heavy alcohol drinking in non-human primates.Alcohol (Fayetteville, N.Y.) · 2019Article
- SNARE Complex-Associated Proteins in the Lateral Amygdala of Macaca mulatta Following Long-Term Ethanol Drinking.Alcoholism, clinical and experimental research · 2018Article
- A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans.Molecular psychiatry · 2018Article
- Synaptic adaptations to chronic ethanol intake in male rhesus monkey dorsal striatum depend on age of drinking onset.Neuropharmacology · 2018Article
- Studies using macaque monkeys to address excessive alcohol drinking and stress interactions.Neuropharmacology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
rationaleConsumption of alcohol begins during late adolescence in a majority of humans, and the greatest drinking occurs at 18-25 years then decreases with age.
objectivesThe present study measured the differences in ethanol intake in relation to age at the onset of ethanol access among nonhuman primates to control for self-selection in humans and isolate age effects on heavy drinking.
methodsMale rhesus macaques were assigned first access to ethanol during late adolescence (n = 8), young adulthood (n = 8), or early middle age (n = 11). The monkeys were induced to drink ethanol (4 % w/v in water) in increasing doses (water then 0.5, 1.0, 1.5 g/kg ethanol) using a fixed-time (FT) 300-s schedule of food delivery, followed by 22 h/day concurrent access to ethanol and water for 12 months. Age-matched controls consumed isocaloric maltose-dextrin solution yoked to the late adolescents expected to be rapidly maturing (n = 4).
resultsYoung adult monkeys had the greatest daily ethanol intake and blood-ethanol concentration (BEC). Only late adolescents escalated their intake (ethanol, not water) during the second compared to the first 6 months of access. On average, plasma testosterone level was consistent with age differences in maturation and tended to increase throughout the experiment more for control than ethanol-drinking adolescent monkeys.
conclusionsYoung adulthood in nonhuman primates strongly disposes toward heavy drinking, which is independent of sociocultural factors present in humans. Ethanol drinking to intoxication during the critical period of late adolescence is associated with escalation to heavy drinking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.