ArticleScientific reports2014
Bdellovibrio bacteriovorus inhibits Staphylococcus aureus biofilm formation and invasion into human epithelial cells.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 98 citations in OpenAlex.
- Eying up predatory bacteria: living antimicrobials for ocular infections.Current opinion in ophthalmology · 2026Review
- From microbes to animals: a review on prey choice and prey-predator dynamics across organismal scales.FEMS microbiology reviews · 2026Review
- Review
- A molecular toolbox to modulate gene expression and protein secretion in the bacterial predator Bdellovibrio bacteriovorus.PLoS genetics · 2025Article
- Quantitative proteome of bacterial periplasmic predation by Bdellovibrio bacteriovorus reveals a prey-lytic protease.Communications biology · 2025Article
- Predation on bacterial pathogens by predatory bacteria of sewage origin: three days prey-predator interactions.BMC microbiology · 2024Article
- How do Gram-negative bacteria escape predation by Bdellovibrio bacteriovorus?npj antimicrobials and resistance · 2024Review
- Predatory Bacteria in the Treatment of Infectious Diseases and Beyond.Infectious disease reports · 2024Review
- Evaluation of the application potential of Bdellovibrio sp. YBD-1 isolated from Yak faeces.Scientific reports · 2024Article
- Predatory bacteria as potential biofilm control and eradication agents in the food industry.Food science and biotechnology · 2023Review
- Moving toward a better understanding of the model bacterial predatorMicrobiology (Reading, England) · 2023Article
- Pairing Colicins B and E5 with Bdellovibrio bacteriovorus To Eradicate Carbapenem- and Colistin-Resistant Strains of Escherichia coli.Microbiology spectrum · 2023Article
- Effect of Predator BacteriaIndian journal of microbiology · 2023Article
- Use of Resazurin To Rapidly EnumerateMicrobiology spectrum · 2022Article
- Biological Control ofMicroorganisms · 2022Review
- Interaction ofMicroorganisms · 2022Article
- The potential of facultative predatoryFrontiers in microbiology · 2022Review
- Antibacterial particles and predatory bacteria as alternatives to antibacterial chemicals in the era of antibiotic resistance.Current opinion in microbiology · 2021Review
- Insights into Bdellovibrio spp. mechanisms of action and potential applications.World journal of microbiology & biotechnology · 2021Review
- iTRAQ®-based quantitative proteomics reveals the proteomic profiling of methicillin-resistant Staphylococcus aureus-derived extracellular vesicles after exposure to imipenem.Folia microbiologica · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bdellovibrio bacteriovorus HD100 is a predatory bacterium that attacks many Gram-negative human pathogens. A serious drawback of this strain, however, is its ineffectiveness against Gram-positive strains, such as the human pathogen Staphylococcus aureus. Here we demonstrate that the extracellular proteases produced by a host-independent B. bacteriovorus (HIB) effectively degrade/inhibit the formation of S. aureus biofilms and reduce its virulence. A 10% addition of HIB supernatant caused a 75% or greater reduction in S. aureus biofilm formation as well as 75% dispersal of pre-formed biofilms. LC-MS-MS analyses identified various B. bacteriovorus proteases within the supernatant, including the serine proteases Bd2269 and Bd2321. Tests with AEBSF confirmed that serine proteases were active in the supernatant and that they impacted S. aureus biofilm formation. The supernatant also possessed a slight DNAse activity. Furthermore, treatment of planktonic S. aureus with the supernatant diminished its ability to invade MCF-10a epithelial cells by 5-fold but did not affect the MCF-10a viability. In conclusion, this study illustrates the hitherto unknown ability of B. bacteriovorus to disperse Gram-positive pathogenic biofilms and mitigate their virulence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.