ArticleeLife2014
Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- The interplay between epidermal cells and the cutaneous sensory nervous: a systematic review.Frontiers in immunology · 2026Pooled it
- Peripheral mechanisms of tactile sensation in fish.Current opinion in neurobiology · 2026Review
- Functional evidence for early origin of tactile acuity in the vertebrate somatosensory system.Current biology : CB · 2025Article
- Sensing multi-directional forces at superresolution using taxel value isoline theory.Nature communications · 2025Article
- A bioinspired tactile scanner for computer haptics.Nature communications · 2024Article
- Biophysical model of muscle spindle encoding.Experimental physiology · 2024Review
- How Merkel cells transduce mechanical stimuli: A biophysical model of Merkel cells.PLoS computational biology · 2023Article
- Neuronal branching is increasingly asymmetric near synapses, potentially enabling plasticity while minimizing energy dissipation and conduction time.Journal of the Royal Society, Interface · 2023Article
- How axon and dendrite branching are guided by time, energy, and spatial constraints.Scientific reports · 2022Article
- Review
- The mechanosensory neurons of touch and their mechanisms of activation.Nature reviews. Neuroscience · 2021Review
- Temporal coherency of mechanical stimuli modulates tactile form perception.Scientific reports · 2021Article
- Contact-electrification-activated artificial afferents at femtojoule energy.Nature communications · 2021Article
- A functional spiking neuronal network for tactile sensing pathway to process edge orientation.Scientific reports · 2021Article
- Article
- The Input-Output Relation of Primary Nociceptive Neurons is Determined by the Morphology of the Peripheral Nociceptive Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Orientation processing by synaptic integration across first-order tactile neurons.PLoS computational biology · 2020Article
- The Macro- and Micro-Mechanics of the Colon and Rectum II: Theoretical and Computational Methods.Bioengineering (Basel, Switzerland) · 2020Review
- Tactile sensory coding and learning with bio-inspired optoelectronic spiking afferent nerves.Nature communications · 2020Article
- The Cellular and Mechanical Basis for Response Characteristics of Identified Primary Afferents in the Rat Vibrissal System.Current biology : CB · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Touch is encoded by cutaneous sensory neurons with diverse morphologies and physiological outputs. How neuronal architecture influences response properties is unknown. To elucidate the origin of firing patterns in branched mechanoreceptors, we combined neuroanatomy, electrophysiology and computation to analyze mouse slowly adapting type I (SAI) afferents. These vertebrate touch receptors, which innervate Merkel cells, encode shape and texture. SAI afferents displayed a high degree of variability in touch-evoked firing and peripheral anatomy. The functional consequence of differences in anatomical architecture was tested by constructing network models representing sequential steps of mechanosensory encoding: skin displacement at touch receptors, mechanotransduction and action-potential initiation. A systematic survey of arbor configurations predicted that the arrangement of mechanotransduction sites at heminodes is a key structural feature that accounts in part for an afferent's firing properties. These findings identify an anatomical correlate and plausible mechanism to explain the driver effect first described by Adrian and Zotterman. DOI: http://dx.doi.org/10.7554/eLife.01488.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.