ReviewCardiovascular research2014
Pregnancy as a cardiac stress model.
Review in Cardiovascular research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 1 synthesis or guideline pooled it, 207 citations in OpenAlex.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- Association of a Lifestyle Intervention with Blood Pressure Trajectories During Pregnancy and Postpartum in Women with Pre-pregnancy Overweight and Obesity.Maternal and child health journal · 2023Trial
- Gestational diabetes promotes future maternal cardiovascular disease through endothelin activation and suppressed NO/cGMP/PRKG and AMPK/SIRT1 signaling pathways.American journal of physiology. Heart and circulatory physiology · 2026Article
- Comment on "Cancer Treatment Modalities and Female Fertility Preservation".Pharmacotherapy · 2026Article
- Antiretroviral therapy in the peripartum period impairs post pregnancy cardiac reverse remodeling in a rodent model.Nature communications · 2026Article
- From bump to pump: extracellular matrix remodeling, dynamics, and biomechanics in the maternal heart.American journal of physiology. Heart and circulatory physiology · 2026Review
- Emerging Role and Potential Therapeutic Application of TRIM Proteins in Cardiovascular Diseases.Biomolecules · 2026Review
- When pregnancy tests the heart: voluntary wheel running attenuates HFHS-associated postpartum hemodynamic dysfunction.American journal of physiology. Heart and circulatory physiology · 2026Article
- Immunometabolism in Cardiac Remodeling: Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Review
- Cardiovascular Disease in Singleton Offspring Born of Pregnancies Complicated by Placental Abruption: A Population-Based Retrospective Cohort Study.Journal of the American Heart Association · 2026Article
- Peripartum cardiomyopathy in an intensive care unit setting.World journal of critical care medicine · 2026Review
- Resuscitation, revival, and birth: a case report of cardiac arrest in a pregnant woman with repaired congenital heart disease.European heart journal. Case reports · 2026Article
- Meteorin-like controls metabolic adaptations and physiological myocardial remodeling in pregnancy and lactation.Frontiers in endocrinology · 2026Article
- The spectrum of pregnancy-induced cardiac remodeling: transitioning from healthy adaptive hypertrophy to peripartum cardiomyopathy.Frontiers in cell and developmental biology · 2026Review
- Shock in Pregnancy - Recommendations of the German Interdisciplinary Association for Intensive and Emergency Medicine (DIVI - Section Shock) and the Working Group on Obstetrics and Prenatal Medicine (AGG - Section on Maternal Disorders).Geburtshilfe und Frauenheilkunde · 2025Article
- Late vs. Early Preeclampsia.International journal of molecular sciences · 2025Review
- Reproductive history and cardiometabolic disease: the role of endogenous estrogen exposure across the lifespan in postmenopausal women.BMC women's health · 2025Article
- Calcium Signaling and Cardiac Adaptation to Stress: Focus on Pregnancy and Diabetes.Biomolecules · 2025Review
- Activation of FoxO1 prevents and reverses cardiac hypertrophy from diverse stimuli.Journal of molecular and cellular cardiology · 2025Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Cardiac hypertrophy occurs during pregnancy as a consequence of both volume overload and hormonal changes. Both pregnancy- and exercise-induced cardiac hypertrophy are generally thought to be similar and physiological. Despite the fact that there are shared transcriptional responses in both forms of cardiac adaptation, pregnancy results in a distinct signature of gene expression in the heart. In some cases, however, pregnancy can induce adverse cardiac events in previously healthy women without any known cardiovascular disease. Peripartum cardiomyopathy is the leading cause of non-obstetric mortality during pregnancy. To understand how pregnancy can cause heart disease, it is first important to understand cardiac adaptation during normal pregnancy. This review provides an overview of the cardiac consequences of pregnancy, including haemodynamic, functional, structural, and morphological adaptations, as well as molecular phenotypes. In addition, this review describes the signalling pathways responsible for pregnancy-induced cardiac hypertrophy and angiogenesis. We also compare and contrast cardiac adaptation in response to disease, exercise, and pregnancy. The comparisons of these settings of cardiac hypertrophy provide insight into pregnancy-associated cardiac adaptation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.