ReviewTranslational psychiatry2014
Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application.
Review in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Biomarkers of neuroprogression and late staging in bipolar disorder: A systematic review.The Australian and New Zealand journal of psychiatry · 2023Pooled it
- Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder.Journal of affective disorders · 2017Trial
- Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder.Scientific reports · 2016Trial
- Choroid plexus inflammation in bipolar disorder.Brain, behavior, and immunity · 2026Article
- Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder.Nature communications · 2026Article
- Neuroserpin, Tissue Plasminogen Activator, Brain-Derived Neurotrophic Factor and Interleukin-6 Serum Levels in Patients with Bipolar Disorder.Noro psikiyatri arsivi · 2026Article
- Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning.PLoS biology · 2025Article
- A unified framework for cell-type-specific eQTL prioritization by integrating bulk and scRNA-seq data.American journal of human genetics · 2025Article
- Maternal immune activation upregulates the AU020206-IRFs-STAT1 axis in modulating cytokine production in the brain.Theranostics · 2024Article
- Association between polymorphisms of TLR2-1-6 and bipolar disorder in a tunisian population.Molecular biology reports · 2023Article
- Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders.Human genetics · 2023Article
- Neuron-Microglia Crosstalk in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2023Review
- Elevated C-reactive protein among symptomatic youth with bipolar disorder.Journal of psychopharmacology (Oxford, England) · 2022Article
- Challenges in Treating Cancer Patients With Unstable Psychiatric Disorder.World journal of oncology · 2021Review
- Neurobehavioral alterations in a mouse model of chronic partial sleep deprivation.Metabolic brain disease · 2021Article
- Clozapine: Why Is It So Uniquely Effective in the Treatment of a Range of Neuropsychiatric Disorders?Biomolecules · 2021Review
- Transcriptomic Deconvolution of Dorsal Striata Reveals Increased Monocyte Fractions in Bipolar Disorder.Complex psychiatry · 2021Article
- Repurposing Immunomodulatory Imide Drugs (IMiDs) in Neuropsychiatric and Neurodegenerative Disorders.Frontiers in neuroscience · 2021Review
- State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders.Life (Basel, Switzerland) · 2020Review
- Effects of Cerebrolysin on Hippocampal Neuronal Death After Pilocarpine-Induced Seizure.Frontiers in neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bipolar disorder (BD) is a debilitating mental illness characterized by severe fluctuations in mood, sleep, energy and executive functioning. Pharmacological studies of selective serotonin reuptake inhibitors and the monoamine system have helped us to clinically understand bipolar depression. Mood stabilizers such as lithium and valproic acid, the first-line treatments for bipolar mania and depression, inhibit glycogen synthase kinase-3 beta (GSK-3β) and regulate the Wnt pathway. Recent investigations suggest that microglia, the resident immune cells of the brain, provide a physiological link between the serotonin system and the GSK-3β/Wnt pathway through neuroinflammation. We review the pharmacological, translational and brain imaging studies that support a role for microglia in regulating neurotransmitter synthesis and immune cell activation. These investigations provide a model for microglia involvement in the pathophysiology and phenotype of BD that may translate into improved therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.