ArticleMolecules (Basel, Switzerland)2014
Synthesis of tetrahydrohonokiol derivates and their evaluation for cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma and HCT-116 colon cancer cells.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter.Molecules (Basel, Switzerland) · 2018Article
- The protective effects of magnolol on acute trinitrobenzene sulfonic acid‑induced colitis in rats.Molecular medicine reports · 2018Article
- Inhibitory effects of magnolol and honokiol on human calcitonin aggregation.Scientific reports · 2015Article
- Honokiol induces cell cycle arrest and apoptosis in human gastric carcinoma MGC-803 cell line.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
6 authors.
Funding
Abstract
Biphenyl neolignans such as honokiol and magnolol, which are the major active constituents of the Asian medicinal plant Magnolia officinalis, are known to exert a multitude of pharmacological and biological activities. Among these, cytotoxic and tumor growth inhibitory activity against various tumour cell lines are well-documented. To further elucidate the cytotoxic effects of honokiol derivatives, derivatizations were performed using tetrahydrohonokiol as a scaffold. The derivatizations comprised the introduction of functional groups, e.g., nitro and amino groups, as well as alkylation. This way, 18 derivatives, of which 13 were previously undescribed compounds, were evaluated against CCRF-CEM leukemia cells, U251 glioblastoma and HCT-116 colon cancer cells. The results revealed no significant cytotoxic effects in any of the three tested cell lines at a test concentration of 10 µM.
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Registered trials
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