ArticleThe Journal of investigative dermatology2014
De novo epidermal regeneration using human eccrine sweat gland cells: higher competence of secretory over absorptive cells.
Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Advances in sweat gland organoids: construction, molecular mechanisms, and challenges.Stem cell research & therapy · 2025Review
- Long-Term Hypoxia Upregulates Wnt and TGFβ1 Signaling in Eccrine Sweat Gland Cells In Vitro.International journal of molecular sciences · 2025Article
- Advances in engineered organoid models of skin for biomedical research.Burns & trauma · 2025Review
- Standard Preparation Protocol of Human Skin and Skin Substitute Samples for Transmission Electron Microscopy.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Ontogeny of Skin Stem Cells and Molecular Underpinnings.Current issues in molecular biology · 2024Review
- Article
- Biological characteristics of stem cells derived from burned skin-a comparative study with umbilical cord stem cells.Stem cell research & therapy · 2021Article
- Eccrine Sweat Gland and Its Regeneration: Current Status and Future Directions.Frontiers in cell and developmental biology · 2021Review
- Sweat gland organoids contribute to cutaneous wound healing and sweat gland regeneration.Cell death & disease · 2019Article
- The expression pattern of keratin 24 in tissue-engineered dermo-epidermal human skin substitutes in an in vivo model.Pediatric surgery international · 2018Article
- Serum is an indispensable factor in the maintenance of the biological characteristics of sweat gland cells.Molecular medicine reports · 2017Article
- Expression of S100A2 and S100P in human eccrine sweat glands and their application in differentiating secretory coil-like from duct-like structures in the 3D reconstituted eccrine sweat spheroids.Journal of molecular histology · 2017Article
- Article
- Eccrine sweat gland development and sweat secretion.Experimental dermatology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our previous work, we showed that human sweat gland-derived epithelial cells represent an alternative source of keratinocytes to grow a near normal autologous epidermis. The role of subtypes of sweat gland cells in epidermal regeneration and maintenance remained unclear. In this study, we compare the regenerative potential of both secretory and absorptive sweat gland cell subpopulations. We demonstrate the superiority of secretory over absorptive cells in forming a new epidermis on two levels: first, the proliferative and colony-forming efficiencies in vitro are significantly higher for secretory cells (SCs), and second, SCs show a higher frequency of successful epidermis formation as well as an increase in the thickness of the formed epidermis in the in vitro and in vivo functional analyses using a 3D dermo-epidermal skin model. However, the ability of forming functional skin substitutes is not limited to SCs, which supports the hypothesis that multiple subtypes of sweat gland epithelial cells hold regenerative properties, while the existence and exact localization of a keratinocyte stem cell population in the human eccrine sweat gland remain elusive.
Indexed as
Identifiers
24448031What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.